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    Luc7l Luc7-like [ Mus musculus (house mouse) ]

    Gene ID: 66978, updated on 5-Aug-2018

    Summary

    Official Symbol
    Luc7lprovided by MGI
    Official Full Name
    Luc7-likeprovided by MGI
    Primary source
    MGI:MGI:1914228
    See related
    Ensembl:ENSMUSG00000024188 Vega:OTTMUSG00000021926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810045C04Rik; 2410018D03Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 20.3), CNS E14 (RPKM 19.8) and 27 other tissues See more
    Orthologs

    Genomic context

    See Luc7l in Genome Data Viewer
    Location:
    17 A3.3; 17 13.09 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (26252899..26285510)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (26389855..26422449)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234, member A Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene transcription elongation factor B polypeptide 1-like Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene hemoglobin alpha, pseudogene 4 Neighboring gene neuralized E3 ubiquitin protein ligase 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RS domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA splice site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative RNA-binding protein Luc7-like 1
    Names
    Luc7 homolog-like

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025881.3NP_080157.1  putative RNA-binding protein Luc7-like 1 isoform 1

      See identical proteins and their annotated locations for NP_080157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK010539, AK160293, BB771481
      Consensus CDS
      CCDS28550.1
      UniProtKB/Swiss-Prot
      Q9CYI4
      UniProtKB/TrEMBL
      A0A0R4J047, Q3TV90
      Related
      ENSMUSP00000025023.7, OTTMUSP00000032671, ENSMUST00000025023.13, OTTMUST00000065532
      Conserved Domains (2) summary
      COG5200
      Location:5230
      LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
      pfam03194
      Location:5241
      LUC7; LUC7 N_terminus
    2. NM_028190.3NP_082466.2  putative RNA-binding protein Luc7-like 1 isoform 2

      See identical proteins and their annotated locations for NP_082466.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, which results in an early stop codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC126438, AK160293, CF951283
      Consensus CDS
      CCDS28549.1
      UniProtKB/Swiss-Prot
      Q9CYI4
      UniProtKB/TrEMBL
      Q3TV90
      Related
      ENSMUSP00000110627.2, OTTMUSP00000032672, ENSMUST00000114976.8, OTTMUST00000065533
      Conserved Domains (1) summary
      pfam03194
      Location:5242
      LUC7; LUC7 N_terminus

    RNA

    1. NR_037905.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC126438, BQ572015, BY726224
      Related
      ENSMUST00000148894.1, OTTMUST00000052057
    2. NR_037906.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC126438
      Related
      ENSMUST00000133032.7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      26252899..26285510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317615.1XP_017173104.1  putative RNA-binding protein Luc7-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9CYI4
      Conserved Domains (1) summary
      pfam03194
      Location:1189
      LUC7; LUC7 N_terminus
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