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    Nuf2 NUF2, NDC80 kinetochore complex component [ Mus musculus (house mouse) ]

    Gene ID: 66977, updated on 26-Sep-2022

    Summary

    Official Symbol
    Nuf2provided by MGI
    Official Full Name
    NUF2, NDC80 kinetochore complex componentprovided by MGI
    Primary source
    MGI:MGI:1914227
    See related
    Ensembl:ENSMUSG00000026683 AllianceGenome:MGI:1914227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdca1; NUF2R; 2410003C07Rik
    Summary
    Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear division. Predicted to act upstream of or within attachment of spindle microtubules to kinetochore. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 19.6), liver E14 (RPKM 14.3) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Nuf2 in Genome Data Viewer
    Location:
    1; 1 H2.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169325503..169359033, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (169497934..169531464, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34535 Neighboring gene predicted gene, 53643 Neighboring gene predicted gene, 34624 Neighboring gene predicted gene, 18900

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Ndc80 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinetochore protein Nuf2
    Names
    cell division cycle-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355159.1NP_001342088.1  kinetochore protein Nuf2

      Status: VALIDATED

      Source sequence(s)
      AK132467, AK162249
      Consensus CDS
      CCDS15463.1
      UniProtKB/Swiss-Prot
      Q9CST5
      Related
      ENSMUSP00000028000.8, ENSMUST00000028000.13
      Conserved Domains (2) summary
      pfam03800
      Location:3145
      Nuf2; Nuf2 family
      cl25732
      Location:166456
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_023284.3NP_075773.2  kinetochore protein Nuf2

      See identical proteins and their annotated locations for NP_075773.2

      Status: VALIDATED

      Source sequence(s)
      AK132467
      Consensus CDS
      CCDS15463.1
      UniProtKB/Swiss-Prot
      Q99P69, Q9CST5
      Related
      ENSMUSP00000106999.2, ENSMUST00000111368.8
      Conserved Domains (2) summary
      pfam03800
      Location:3145
      Nuf2; Nuf2 family
      cl25732
      Location:166456
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      169325503..169359033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)