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    Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [ Mus musculus (house mouse) ]

    Gene ID: 66945, updated on 26-Jun-2024


    Official Symbol
    Sdhaprovided by MGI
    Official Full Name
    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000021577 AllianceGenome:MGI:1914195
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FP; SDH2; SDHF; 4921513A11; 1500032O14Rik; 2310034D06Rik
    Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone; nervous system development; and succinate metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in heart adult (RPKM 297.9), kidney adult (RPKM 187.0) and 28 other tissues See more
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    Genomic context

    See Sdha in Genome Data Viewer
    13 C1; 13 40.15 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74470374..74498359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74322255..74350240, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene aryl-hydrocarbon receptor repressor Neighboring gene programmed cell death 6 Neighboring gene STARR-positive B cell enhancer ABC_E10800 Neighboring gene coiled-coil domain containing 127 Neighboring gene leucine rich repeat containing 14B Neighboring gene zinc finger protein 72 Neighboring gene BCL2-like 13 (apoptosis facilitator) pseudogene

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    enables succinate dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables succinate dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    contributes_to succinate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info

    General protein information

    Preferred Names
    succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    flavoprotein subunit of complex II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023281.1NP_075770.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_075770.1

      Status: VALIDATED

      Source sequence(s)
      AK010561, AK034928
      Consensus CDS
      Q0QF19, Q3UH25, Q3UKP7, Q3V4B1, Q8K2B3, Q921P5, Q9Z1Z4
      ENSMUSP00000022062.8, ENSMUST00000022062.8
      Conserved Domains (3) summary
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000079.7 Reference GRCm39 C57BL/6J

      74470374..74498359 complement
      GenBank, FASTA, Sequence Viewer (Graphics)