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    Cir1 corepressor interacting with RBPJ, 1 [ Mus musculus (house mouse) ]

    Gene ID: 66935, updated on 18-Sep-2024

    Summary

    Official Symbol
    Cir1provided by MGI
    Official Full Name
    corepressor interacting with RBPJ, 1provided by MGI
    Primary source
    MGI:MGI:1914185
    See related
    Ensembl:ENSMUSG00000041777 AllianceGenome:MGI:1914185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cir; Cicr; 1700023B02Rik; 2810021A19Rik
    Summary
    Predicted to enable histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within in utero embryonic development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in genitourinary system and limb ectoderm. Orthologous to human CIR1 (corepressor interacting with RBPJ, CIR1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 12.7), testis adult (RPKM 10.9) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Cir1 in Genome Data Viewer
    Location:
    2 C3; 2 43.54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73113445..73142922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73283872..73312592, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Obg-like ATPase 1 Neighboring gene STARR-seq mESC enhancer starr_04836 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene trans-acting transcription factor 9 Neighboring gene STARR-positive B cell enhancer ABC_E2622 Neighboring gene secernin 3 Neighboring gene STARR-seq mESC enhancer starr_04837 Neighboring gene G protein-coupled receptor 155 Neighboring gene predicted gene 13709

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117636

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    corepressor interacting with RBPJ 1
    Names
    CBF1 interacting corepressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025854.4NP_080130.2  corepressor interacting with RBPJ 1

      See identical proteins and their annotated locations for NP_080130.2

      Status: VALIDATED

      Source sequence(s)
      AL954713
      Consensus CDS
      CCDS16127.1
      UniProtKB/Swiss-Prot
      Q3V2N9, Q4KL44, Q52KL9, Q5FW66, Q9DA19
      Related
      ENSMUSP00000049834.10, ENSMUST00000058615.10
      Conserved Domains (1) summary
      pfam10197
      Location:1349
      Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      73113445..73142922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)