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    Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein [ Mus musculus (house mouse) ]

    Gene ID: 66925, updated on 8-Feb-2024


    Official Symbol
    Sdhdprovided by MGI
    Official Full Name
    succinate dehydrogenase complex, subunit D, integral membrane proteinprovided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000000171 AllianceGenome:MGI:1914175
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    QPs3; cybS; CII-4; AVLL5809; PRO19626; 3110001M13Rik
    Enables succinate dehydrogenase (ubiquinone) activity. Acts upstream of or within cellular response to hypoxia and regulation of catecholamine secretion. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in heart adult (RPKM 247.8), duodenum adult (RPKM 208.9) and 28 other tissues See more
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    Genomic context

    See Sdhd in Genome Data Viewer
    9 A5.3; 9 27.75 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50507640..50515149, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50596340..50603849, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:50341457-50341566 Neighboring gene beta-carotene oxygenase 2 Neighboring gene interleukin 18 Neighboring gene testis expressed 12 Neighboring gene translocase of inner mitochondrial membrane 8B Neighboring gene NKAP domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:50425377-50425486 Neighboring gene PIH1 domain containing 2

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    enables succinate dehydrogenase (quinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    enables ubiquinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
    succinate dehydrogenase complex subunit D
    succinate-ubiquinone oxidoreductase cytochrome b small subunit
    succinate-ubiquinone reductase membrane anchor subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025848.3NP_080124.1  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

      See identical proteins and their annotated locations for NP_080124.1

      Status: VALIDATED

      Source sequence(s)
      AC025500, AK135970, BF662071
      Consensus CDS
      A6H629, Q3UX11, Q9CXV1
      ENSMUSP00000000175.5, ENSMUST00000000175.6
      Conserved Domains (1) summary
      SQR_TypeC_CybS; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Eukaryotic SQRs reduce high potential quinones such as ubiquinone. SQR is also called succinate dehydrogenase or Complex II, and is part of the citric ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000075.7 Reference GRCm39 C57BL/6J

      50507640..50515149 complement
      GenBank, FASTA, Sequence Viewer (Graphics)