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    Baiap2l1 BAI1-associated protein 2-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 66898, updated on 27-Nov-2024

    Summary

    Official Symbol
    Baiap2l1provided by MGI
    Official Full Name
    BAI1-associated protein 2-like 1provided by MGI
    Primary source
    MGI:MGI:1914148
    See related
    Ensembl:ENSMUSG00000038859 AllianceGenome:MGI:1914148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IRTKS; 1300006M19Rik
    Summary
    Predicted to enable proline-rich region binding activity. Predicted to be involved in actin crosslink formation; actin filament bundle assembly; and positive regulation of actin filament polymerization. Predicted to be located in plasma membrane. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with actin cytoskeleton. Is expressed in several structures, including brain; gut; lung; and nose. Orthologous to human BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 37.6), stomach adult (RPKM 27.4) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Baiap2l1 in Genome Data Viewer
    Location:
    5 G2; 5 83.24 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144201335..144294922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144264525..144358112, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2183 Neighboring gene RIKEN cDNA 2900089D17 gene Neighboring gene brain protein I3 Neighboring gene predicted gene 15708 Neighboring gene STARR-seq mESC enhancer starr_14808 Neighboring gene Dmrt1 interacting ncRNA Neighboring gene STARR-seq mESC enhancer starr_14810 Neighboring gene predicted gene, 33552 Neighboring gene STARR-seq mESC enhancer starr_14811 Neighboring gene STARR-seq mESC enhancer starr_14813 Neighboring gene predicted gene, 33714

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    BAR/IMD domain-containing adapter protein 2-like 1
    Names
    BAI1-associated protein 2-like protein 1
    brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
    insulin receptor tyrosine kinase substrate

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025833.3NP_080109.1  BAR/IMD domain-containing adapter protein 2-like 1

      See identical proteins and their annotated locations for NP_080109.1

      Status: VALIDATED

      Source sequence(s)
      AK004918, AV224233
      Consensus CDS
      CCDS39378.1
      UniProtKB/Swiss-Prot
      Q9DBJ3
      Related
      ENSMUSP00000053129.8, ENSMUST00000055190.8
      Conserved Domains (2) summary
      cd07645
      Location:6231
      I-BAR_IMD_BAIAP2L1; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1
      cd11913
      Location:343400
      SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      144201335..144294922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)