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    Mfsd1 major facilitator superfamily domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66868, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mfsd1provided by MGI
    Official Full Name
    major facilitator superfamily domain containing 1provided by MGI
    Primary source
    MGI:MGI:1914118
    See related
    Ensembl:ENSMUSG00000027775 AllianceGenome:MGI:1914118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200003O06Rik
    Summary
    Enables protein homodimerization activity. Involved in dipeptide transmembrane transport from lysosomal lumen to cytosol; protein localization to lysosome; and protein stabilization. Located in lysosome. Is active in lysosomal membrane. Is expressed in embryo and renal vasculature. Orthologous to human MFSD1 (major facilitator superfamily domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 75.5), placenta adult (RPKM 43.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Mfsd1 in Genome Data Viewer
    Location:
    3 E1; 3 31.07 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67490101..67511564)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67582768..67604231)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35299 Neighboring gene STARR-seq mESC enhancer starr_07890 Neighboring gene STARR-seq mESC enhancer starr_07891 Neighboring gene STARR-positive B cell enhancer ABC_E8801 Neighboring gene STARR-positive B cell enhancer ABC_E11190 Neighboring gene predicted gene, 25919 Neighboring gene STARR-positive B cell enhancer ABC_E4547 Neighboring gene STARR-seq mESC enhancer starr_07892 Neighboring gene chromatin modifying protein 1A pseudogene Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dipeptide uniporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dipeptide uniporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysosomal dipeptide transporter MFSD1
    Names
    major facilitator superfamily domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025813.3NP_080089.1  lysosomal dipeptide transporter MFSD1

      See identical proteins and their annotated locations for NP_080089.1

      Status: VALIDATED

      Source sequence(s)
      AC135635
      Consensus CDS
      CCDS38450.1
      UniProtKB/Swiss-Prot
      Q3UWU0, Q8BVZ3, Q9DC37
      Related
      ENSMUSP00000029344.9, ENSMUST00000029344.10
      Conserved Domains (2) summary
      cd06174
      Location:45438
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:48402
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      67490101..67511564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)