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    Ube2w ubiquitin-conjugating enzyme E2W (putative) [ Mus musculus (house mouse) ]

    Gene ID: 66799, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ube2wprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2W (putative)provided by MGI
    Primary source
    MGI:MGI:1914049
    See related
    Ensembl:ENSMUSG00000025939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6130401J04Rik
    Expression
    Broad expression in CNS E18 (RPKM 4.9), cortex adult (RPKM 4.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Ube2w in Genome Data Viewer
    Location:
    1; 1 A3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (16611012..16689676, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (16540788..16619460, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (16559487..16609367, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene predicted gene 7568 Neighboring gene RIKEN cDNA C130013N14 gene Neighboring gene RIKEN cDNA D030040B21 gene Neighboring gene elongin C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 W
    Names
    E2 ubiquitin-conjugating enzyme W
    N-terminal E2 ubiquitin-conjugating enzyme
    N-terminus-conjugating E2
    probable ubiquitin-conjugating enzyme E2 W
    ubiquitin carrier protein W
    ubiquitin-protein ligase W
    NP_001257945.2
    NP_001257946.2
    NP_080049.3
    XP_006495620.1
    XP_011236704.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271016.2NP_001257945.2  ubiquitin-conjugating enzyme E2 W isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and has alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
      Source sequence(s)
      AK050923, BE994510
      Consensus CDS
      CCDS87815.1
      Related
      ENSMUSP00000138110.3, ENSMUST00000182554.9
      Conserved Domains (1) summary
      cl00154
      Location:770
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001271017.2NP_001257946.2  ubiquitin-conjugating enzyme E2 W isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC162448, BY728312, CN663576
      Conserved Domains (1) summary
      cl00154
      Location:770
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_025773.4NP_080049.3  ubiquitin-conjugating enzyme E2 W isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC162448, AK082233, BY728312
      Consensus CDS
      CCDS48224.3
      Related
      ENSMUSP00000112741.4, ENSMUST00000117146.9
      Conserved Domains (1) summary
      pfam00179
      Location:7148
      UQ_con; Ubiquitin-conjugating enzyme

    RNA

    1. NR_073122.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC162448, BY728312, DV044691

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      16611012..16689676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238402.4XP_011236704.1  ubiquitin-conjugating enzyme E2 W isoform X2

      Conserved Domains (1) summary
      cl00154
      Location:3699
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_006495557.5XP_006495620.1  ubiquitin-conjugating enzyme E2 W isoform X1

      Conserved Domains (1) summary
      pfam00179
      Location:36148
      UQ_con; Ubiquitin-conjugating enzyme

    RNA

    1. XR_003946406.2 RNA Sequence

    2. XR_004934078.1 RNA Sequence

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