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    Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66724, updated on 8-Aug-2021

    Summary

    Official Symbol
    Tab3provided by MGI
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 3provided by MGI
    Primary source
    MGI:MGI:1913974
    See related
    Ensembl:ENSMUSG00000035476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map3k; Map3k7ip3; mKIAA4135; 4921526G09Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.3), placenta adult (RPKM 4.2) and 27 other tissues See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See Tab3 in Genome Data Viewer
    Location:
    X; X C1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (84617466..84678075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (85573854..85634469)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (82819361..82879808)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 16463 Neighboring gene ferritin, heavy polypeptide-like 17, member A Neighboring gene predicted gene, 39523 Neighboring gene glycerol kinase Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene TLR adaptor interacting with endolysosomal SLC15A4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA4135

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Names
    TAK1-binding protein 3
    TGF-beta-activated kinase 1-binding protein 3
    mitogen-activated protein kinase kinase kinase 7-interacting protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358447.1NP_001345376.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      AL645567, AL645586, BC090666
      Consensus CDS
      CCDS41049.1
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    2. NM_025729.4NP_080005.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

      See identical proteins and their annotated locations for NP_080005.2

      Status: VALIDATED

      Source sequence(s)
      AK048222, AK220185, BC090666
      Consensus CDS
      CCDS41049.1
      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9, Q9D5S8
      Related
      ENSMUSP00000039668.4, ENSMUST00000048250.10
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      84617466..84678075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251478.2XP_030107338.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    2. XM_030251476.2XP_030107336.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    3. XM_030251479.2XP_030107339.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    4. XM_006528238.5XP_006528301.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528301.1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    5. XM_030251477.2XP_030107337.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    6. XM_006528239.4XP_006528302.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528302.1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RNA

    1. XR_003953021.2 RNA Sequence

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