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    Actr2 ARP2 actin-related protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 66713, updated on 31-Jan-2019

    Summary

    Official Symbol
    Actr2provided by MGI
    Official Full Name
    ARP2 actin-related protein 2provided by MGI
    Primary source
    MGI:MGI:1913963
    See related
    Ensembl:ENSMUSG00000020152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp2; AA409782; D6Ertd746e; 4921510D23Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 51.3), CNS E18 (RPKM 43.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See Actr2 in Genome Data Viewer
    Location:
    11 A3.1; 11 12.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (20062304..20112951, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (19962307..20012954, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39603 Neighboring gene predicted gene, 32080 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene predicted gene 12031

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36604

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to interferon-gamma IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosolic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic chromosome movement towards spindle pole IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    spindle localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    actin cap IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    invadopodium ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    podosome core ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2
    Names
    ARP2 actin-related protein 2 homolog
    actin-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362899.1NP_001349828.1  actin-related protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606522, BP753259
      Conserved Domains (1) summary
      smart00268
      Location:6393
      ACTIN; Actin
    2. NM_146243.2NP_666355.1  actin-related protein 2 isoform 2

      See identical proteins and their annotated locations for NP_666355.1

      Status: VALIDATED

      Source sequence(s)
      AK032832, BE448820, BP753259, BY278998
      Consensus CDS
      CCDS24455.1
      UniProtKB/Swiss-Prot
      P61161
      UniProtKB/TrEMBL
      Q5SW83
      Related
      ENSMUSP00000000137.7, ENSMUST00000000137.7
      Conserved Domains (1) summary
      smart00268
      Location:6388
      ACTIN; Actin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      20062304..20112951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514780.3XP_006514843.1  actin-related protein 2 isoform X1

      Conserved Domains (1) summary
      smart00268
      Location:6393
      ACTIN; Actin
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