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    Sbds SBDS ribosome maturation factor [ Mus musculus (house mouse) ]

    Gene ID: 66711, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sbdsprovided by MGI
    Official Full Name
    SBDS ribosome maturation factorprovided by MGI
    Primary source
    MGI:MGI:1913961
    See related
    Ensembl:ENSMUSG00000025337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SDS; CGI-97; AI836084; 4733401P19Rik
    Summary
    This gene encodes a protein that is necessary for ribosome function and maintaining normal levels of protein synthesis. The encoded protein may function to activate ribosomes for translation, and may be involved in cellular response to stress and DNA damage. Loss of this gene is embryonic lethal while deficiency of the encoded protein in the pancreas is associated with symptoms of Shwachman-Diamond syndrome. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in bladder adult (RPKM 34.3), placenta adult (RPKM 26.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sbds in Genome Data Viewer
    Location:
    5; 5 G1.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130274573..130284371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130245732..130255530, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (130721602..130731332, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RAB guanine nucleotide exchange factor (GEF) 1 Neighboring gene predicted gene 15921 Neighboring gene transmembrane protein 248 Neighboring gene predicted gene 6598 Neighboring gene tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) Neighboring gene predicted gene, 40336 Neighboring gene calneuron 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bone marrow development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner cell mass cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mature ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosome maturation protein SBDS
    Names
    SBDS ribosome assembly guanine nucleotide exchange factor
    Shwachman-Bodian-Diamond syndrome homolog
    protein 22A3
    shwachman-Bodian-Diamond syndrome protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023248.2NP_075737.1  ribosome maturation protein SBDS

      See identical proteins and their annotated locations for NP_075737.1

      Status: REVIEWED

      Source sequence(s)
      AI836084, AK014648, BY311303
      Consensus CDS
      CCDS19710.1
      UniProtKB/Swiss-Prot
      P70122
      Related
      ENSMUSP00000026387.5, ENSMUST00000026387.11
      Conserved Domains (3) summary
      COG1500
      Location:9241
      Sdo1; Ribosome maturation protein Sdo1 [Translation, ribosomal structure and biogenesis]
      pfam01172
      Location:1798
      SBDS; Shwachman-Bodian-Diamond syndrome (SBDS) protein
      pfam09377
      Location:107224
      SBDS_C; SBDS protein C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      130274573..130284371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504490.4XP_006504553.1  ribosome maturation protein SBDS isoform X1

      Conserved Domains (1) summary
      pfam09377
      Location:1119
      SBDS_C; SBDS protein C-terminal domain
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