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    Atg4a autophagy related 4A, cysteine peptidase [ Mus musculus (house mouse) ]

    Gene ID: 666468, updated on 10-Oct-2019

    Summary

    Official Symbol
    Atg4aprovided by MGI
    Official Full Name
    autophagy related 4A, cysteine peptidaseprovided by MGI
    Primary source
    MGI:MGI:2147903
    See related
    Ensembl:ENSMUSG00000079418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apg4a; Autl2; Atg4al; AI627006; AV169859
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Broad expression in genital fat pad adult (RPKM 11.0), placenta adult (RPKM 5.0) and 20 other tissues See more
    Orthologs

    Genomic context

    See Atg4a in Genome Data Viewer
    Location:
    X; X F1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140953877..141164270)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (137491456..137529979) , (137593241..137598813)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene V-set and immunoglobulin domain containing 1 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Neighboring gene collagen, type IV, alpha 6 Neighboring gene predicted gene, 39539 Neighboring gene prohibitin pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - other, organism-specific biosystem (from KEGG)
      Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - other, conserved biosystem (from KEGG)
      Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC107179

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cysteine protease ATG4A
    Names
    APG4 (ATG4) autophagy-related homolog A
    AUT-like 2, cysteine endopeptidase
    autophagin 2
    autophagy 4 homolog A
    autophagy-related 4A
    autophagy-related cysteine endopeptidase 2
    autophagy-related protein 4 homolog A
    cysteine protease APG4A
    NP_777364.3
    XP_017174088.1
    XP_017174089.1
    XP_017174090.1
    XP_017174091.1
    XP_017174092.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174875.4NP_777364.3  cysteine protease ATG4A

      See identical proteins and their annotated locations for NP_777364.3

      Status: VALIDATED

      Source sequence(s)
      AK041379, BB638045, BY287162, CJ057919, CK023195
      Consensus CDS
      CCDS85810.1
      UniProtKB/Swiss-Prot
      Q8C9S8
      UniProtKB/TrEMBL
      Q5EBK1
      Related
      ENSMUSP00000108595.1, ENSMUST00000112971.1
      Conserved Domains (1) summary
      pfam03416
      Location:43332
      Peptidase_C54; Peptidase family C54

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p6 C57BL/6J

      Range
      140953877..141164270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318599.2XP_017174088.1  cysteine protease ATG4A isoform X1

    2. XM_017318600.2XP_017174089.1  cysteine protease ATG4A isoform X2

    3. XM_017318603.2XP_017174092.1  cysteine protease ATG4A isoform X4

    4. XM_017318602.2XP_017174091.1  cysteine protease ATG4A isoform X3

    5. XM_017318601.2XP_017174090.1  cysteine protease ATG4A isoform X3

    Reference GRCm38.p6 PATCHES

    Genomic

    1. NW_019168531.1 Reference GRCm38.p6 PATCHES

      Range
      172146..261756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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