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    Mcm8 minichromosome maintenance 8 homologous recombination repair factor [ Mus musculus (house mouse) ]

    Gene ID: 66634, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mcm8provided by MGI
    Official Full Name
    minichromosome maintenance 8 homologous recombination repair factorprovided by MGI
    Primary source
    MGI:MGI:1913884
    See related
    Ensembl:ENSMUSG00000027353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730432L01Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 3.0) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mcm8 in Genome Data Viewer
    Location:
    2; 2 F2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132658061..132686117)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132816137..132844197)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132642071..132669933)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 1 Neighboring gene predicted gene, 52525 Neighboring gene predicted gene, 22245 Neighboring gene chromogranin B Neighboring gene tRNA methyltransferase 6 Neighboring gene cardiolipin synthase 1 Neighboring gene leucine rich repeat neuronal 4 Neighboring gene predicted gene, 54154

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MutLbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MutSbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MCM8-MCM9 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MCM8-MCM9 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA helicase MCM8
    Names
    DNA replication licensing factor MCM8
    minichromosome maintenance deficient 8
    NP_001277983.1
    NP_079952.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291054.1NP_001277983.1  DNA helicase MCM8 isoform a

      See identical proteins and their annotated locations for NP_001277983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC046780, BC052070, BY766288
      Consensus CDS
      CCDS71152.1
      UniProtKB/Swiss-Prot
      Q9CWV1
      Related
      ENSMUSP00000028831.9, ENSMUST00000028831.15
      Conserved Domains (4) summary
      cd00009
      Location:428586
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG1241
      Location:132830
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      pfam14551
      Location:91216
      MCM_N; MCM N-terminal domain
      cl21521
      Location:676747
      PEPcase; Phosphoenolpyruvate carboxylase
    2. NM_025676.4NP_079952.2  DNA helicase MCM8 isoform b

      See identical proteins and their annotated locations for NP_079952.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK133858, BC052070, BY766288
      Consensus CDS
      CCDS16778.1
      UniProtKB/Swiss-Prot
      Q9CWV1
      Related
      ENSMUSP00000066842.6, ENSMUST00000066559.6
      Conserved Domains (4) summary
      cd00009
      Location:400558
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG1241
      Location:104802
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      pfam14551
      Location:63188
      MCM_N; MCM N-terminal domain
      cl21521
      Location:648719
      PEPcase; Phosphoenolpyruvate carboxylase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132658061..132686117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003953691.2 RNA Sequence

    2. XR_004940695.1 RNA Sequence

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