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    Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 66624, updated on 13-Oct-2022

    Summary

    Official Symbol
    Spcs2provided by MGI
    Official Full Name
    signal peptidase complex subunit 2 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1913874
    See related
    Ensembl:ENSMUSG00000035227 AllianceGenome:MGI:1913874
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0102; 5730406I15Rik
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and urinary system. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 23.9), CNS E11.5 (RPKM 21.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Spcs2 in Genome Data Viewer
    Location:
    7; 7 E1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99486776..99514143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99837569..99870340, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor enhancer Ikaria Neighboring gene neuraminidase 3 Neighboring gene X-ray radiation resistance associated 1 Neighboring gene predicted gene, 38405 Neighboring gene ring finger protein 169 Neighboring gene predicted gene 5115

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC60452

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of signal peptidase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal peptidase complex subunit 2
    Names
    SPase 25 kDa subunit
    microsomal signal peptidase 25 kDa subunit
    NP_079944.1
    XP_006508180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025668.3NP_079944.1  signal peptidase complex subunit 2

      See identical proteins and their annotated locations for NP_079944.1

      Status: PROVISIONAL

      Source sequence(s)
      AK134578
      Consensus CDS
      CCDS40033.1
      UniProtKB/Swiss-Prot
      Q9CXK1, Q9CYN2
      UniProtKB/TrEMBL
      A0A6P5Q8E5, A0A8C6I900
      Related
      ENSMUSP00000041152.7, ENSMUST00000036274.8
      Conserved Domains (1) summary
      pfam06703
      Location:61216
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99486776..99514143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508117.4XP_006508180.1  signal peptidase complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A140LHR3, A0A8C6I9N4
      Related
      ENSMUSP00000146514.2, ENSMUST00000207063.2
      Conserved Domains (1) summary
      pfam06703
      Location:25181
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)