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    Ntmt1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66617, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ntmt1provided by MGI
    Official Full Name
    N-terminal Xaa-Pro-Lys N-methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1913867
    See related
    Ensembl:ENSMUSG00000026857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NTM1A; AL033331; AL033332; Mettl11a; 2610205E22Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 27.0), adrenal adult (RPKM 21.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ntmt1 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (30807779..30823026)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (30663497..30678534)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39784 Neighboring gene RIKEN cDNA 1700001O22 gene Neighboring gene ankyrin repeat and SOCS box-containing 6 Neighboring gene paired related homeobox 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Chemically induced (ENU) (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25577

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    N-terminal protein N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    N-terminal protein N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    N-terminal peptidyl-alanine trimethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    N-terminal peptidyl-glycine methylation ISO
    Inferred from Sequence Orthology
    more info
     
    N-terminal peptidyl-proline dimethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    N-terminal peptidyl-proline dimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    N-terminal peptidyl-serine dimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    N-terminal peptidyl-serine trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    N-terminal protein amino acid methylation IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
    Names
    X-Pro-Lys N-terminal protein methyltransferase 1A
    alpha N-terminal protein methyltransferase 1A
    methyltransferase like 11A
    methyltransferase-like protein 11A
    NP_733480.1
    XP_006498289.1
    XP_006498291.1
    XP_006498292.1
    XP_006498293.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356433.1NP_001343362.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL844532
      Conserved Domains (1) summary
      pfam05891
      Location:8223
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase
    2. NM_001356434.1NP_001343363.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL844532
      Conserved Domains (1) summary
      cl17173
      Location:26193
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001356435.1NP_001343364.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (c).
      Source sequence(s)
      AL844532, FO719400
      Conserved Domains (1) summary
      cl17173
      Location:1135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. NM_001356436.1NP_001343365.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (c).
      Source sequence(s)
      AL844532, FO713235
      Conserved Domains (1) summary
      cl17173
      Location:1135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. NM_001356437.1NP_001343366.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (c).
      Source sequence(s)
      AL844532
      Conserved Domains (1) summary
      cl17173
      Location:1135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    6. NM_170592.3NP_733480.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform a

      See identical proteins and their annotated locations for NP_733480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL844532, FO719547
      Consensus CDS
      CCDS15886.1
      UniProtKB/Swiss-Prot
      Q8R2U4
      Related
      ENSMUSP00000035303.3, ENSMUST00000041830.9
      Conserved Domains (1) summary
      pfam05891
      Location:8223
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase

    RNA

    1. NR_151467.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AL844532, BY290960
    2. NR_151468.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AK161700, AL844532

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      30807779..30823026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498229.3XP_006498292.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:1135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_006498226.3XP_006498289.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8R2U4
      Conserved Domains (1) summary
      pfam05891
      Location:8223
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase
    3. XM_006498230.3XP_006498293.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:1135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_006498228.3XP_006498291.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:26193
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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