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    Abi3 ABI family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 66610, updated on 23-Jun-2021

    Summary

    Official Symbol
    Abi3provided by MGI
    Official Full Name
    ABI family member 3provided by MGI
    Primary source
    MGI:MGI:1913860
    See related
    Ensembl:ENSMUSG00000018381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NESH; AI987680; 2210414K06Rik
    Expression
    Broad expression in thymus adult (RPKM 38.5), duodenum adult (RPKM 25.3) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Abi3 in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95720898..95733302, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95830072..95842476, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (95691386..95703790, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29933 Neighboring gene phosphatase, orphan 1 Neighboring gene predicted gene, 38958 Neighboring gene guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 Neighboring gene RIKEN cDNA 4833417C18 gene Neighboring gene predicted gene, 38959 Neighboring gene nuclear encoded tRNA glutamine 6 (anticodon TTG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCAR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular anatomical structure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    ABI gene family member 3
    Names
    ABI gene family, member 3
    new molecule including SH3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163464.1NP_001156936.1  ABI gene family member 3 isoform 2

      See identical proteins and their annotated locations for NP_001156936.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences causes translation initiation at a downstream AUG and results an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK037144, AL593858
      UniProtKB/Swiss-Prot
      Q8BYZ1
      Conserved Domains (2) summary
      cd11826
      Location:260311
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:43114
      Abi_HHR; Abl-interactor HHR
    2. NM_025659.4NP_079935.1  ABI gene family member 3 isoform 1

      See identical proteins and their annotated locations for NP_079935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK008928, AL593858
      Consensus CDS
      CCDS25283.1
      UniProtKB/Swiss-Prot
      Q8BYZ1
      Related
      ENSMUSP00000061893.4, ENSMUST00000059026.10
      Conserved Domains (2) summary
      cd11826
      Location:313364
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96167
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95720898..95733302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246225.2XP_030102085.1  ABI gene family member 3 isoform X4

      Conserved Domains (2) summary
      cd11826
      Location:312363
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96167
      Abi_HHR; Abl-interactor HHR
    2. XM_030246228.2XP_030102088.1  ABI gene family member 3 isoform X6

      Conserved Domains (2) summary
      cd11826
      Location:271321
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:96167
      Abi_HHR; Abl-interactor HHR
    3. XM_017314710.3XP_017170199.1  ABI gene family member 3 isoform X7

      UniProtKB/Swiss-Prot
      Q8BYZ1
      Conserved Domains (2) summary
      cd11826
      Location:260311
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:43114
      Abi_HHR; Abl-interactor HHR
    4. XM_017314709.2XP_017170198.1  ABI gene family member 3 isoform X3

      Conserved Domains (2) summary
      cd11826
      Location:328379
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR
    5. XM_006533956.3XP_006534019.1  ABI gene family member 3 isoform X5

      Conserved Domains (2) summary
      cd11826
      Location:288338
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR
    6. XM_017314708.1XP_017170197.1  ABI gene family member 3 isoform X2

      Conserved Domains (2) summary
      cd11826
      Location:328379
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR
    7. XM_017314707.1XP_017170196.1  ABI gene family member 3 isoform X1

      Conserved Domains (2) summary
      cd11826
      Location:329380
      SH3_Abi; Src homology 3 domain of Abl Interactor proteins
      pfam07815
      Location:112183
      Abi_HHR; Abl-interactor HHR
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