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    Gtf3a general transcription factor III A [ Mus musculus (house mouse) ]

    Gene ID: 66596, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gtf3aprovided by MGI
    Official Full Name
    general transcription factor III Aprovided by MGI
    Primary source
    MGI:MGI:1913846
    See related
    Ensembl:ENSMUSG00000016503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010015D03Rik; 2610111I01Rik; 5330403M05Rik
    Summary
    The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary adult (RPKM 66.8), colon adult (RPKM 54.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gtf3a in Genome Data Viewer
    Location:
    5; 5 G3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (146948657..146955614)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (147760233..147767190)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RAS-like, family 11, member A Neighboring gene predicted gene, 38748 Neighboring gene mitochondrial translational initiation factor 3 Neighboring gene predicted gene, 46936 Neighboring gene ligand of numb-protein X 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    5S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor IIIA
    Names
    TFIIIA
    factor A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025652.3NP_079928.2  transcription factor IIIA

      See identical proteins and their annotated locations for NP_079928.2

      Status: REVIEWED

      Source sequence(s)
      AC124828, AF391799, BE656279, BI202484
      Consensus CDS
      CCDS19873.2
      UniProtKB/Swiss-Prot
      Q8VHT7
      Related
      ENSMUSP00000119607.1, ENSMUST00000146511.7
      Conserved Domains (2) summary
      COG5048
      Location:62185
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:4362
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      146948657..146955614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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