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    Mad2l1bp MAD2L1 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 66591, updated on 26-Sep-2022

    Summary

    Official Symbol
    Mad2l1bpprovided by MGI
    Official Full Name
    MAD2L1 binding proteinprovided by MGI
    Primary source
    MGI:MGI:1913841
    See related
    Ensembl:ENSMUSG00000034509 AllianceGenome:MGI:1913841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CMT2A; CMT2B; Mad2lbp; mKIAA0110; 0610009D16Rik; 2510031P20Rik
    Summary
    Predicted to be involved in deactivation of mitotic spindle assembly checkpoint and regulation of exit from mitosis. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleus. Orthologous to human MAD2L1BP (MAD2L1 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 16.5), large intestine adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mad2l1bp in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46458311..46464477, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46147385..46153551, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene radial spoke head 9 homolog (Chlamydomonas) Neighboring gene GTP binding protein 2 Neighboring gene polymerase (DNA directed), eta (RAD 30 related)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0110

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025649.3NP_079925.2  MAD2L1-binding protein

      See identical proteins and their annotated locations for NP_079925.2

      Status: VALIDATED

      Source sequence(s)
      AC110562, AI851249, AK004224
      Consensus CDS
      CCDS28821.1
      UniProtKB/Swiss-Prot
      Q9D0Y3, Q9DCX1
      Related
      ENSMUSP00000125915.2, ENSMUST00000171172.3
      Conserved Domains (1) summary
      pfam06581
      Location:41276
      p31comet; Mad1 and Cdc20-bound-Mad2 binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46458311..46464477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)