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    Ube2v1 ubiquitin-conjugating enzyme E2 variant 1 [ Mus musculus (house mouse) ]

    Gene ID: 66589, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ube2v1provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2 variant 1provided by MGI
    Primary source
    MGI:MGI:1913839
    See related
    Ensembl:ENSMUSG00000078923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRO; CROC1; UEV-1; CROC-1; AI256840; D7Bwg1382e; 0610011J09Rik
    Expression
    Ubiquitous expression in stomach adult (RPKM 69.4), frontal lobe adult (RPKM 57.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube2v1 in Genome Data Viewer
    Location:
    2 H3; 2 87.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167449559..167473933, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167607639..167632020, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (167433139..167457505, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 11476 Neighboring gene predicted gene, 31619 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene predicted gene, 31852 Neighboring gene plasmanylethanolamine desaturase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin conjugating enzyme activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within error-free postreplication DNA repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of UBC13-UEV1A complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of ubiquitin conjugating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 variant 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311131.1NP_001298060.1  ubiquitin-conjugating enzyme E2 variant 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158230, CF171728
      Consensus CDS
      CCDS79868.1
      UniProtKB/TrEMBL
      B7ZBY7, Q569Y6
      Related
      ENSMUSP00000114764.2, ENSMUST00000151365.8
      Conserved Domains (1) summary
      smart00212
      Location:42168
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    2. NM_001311146.1NP_001298075.1  ubiquitin-conjugating enzyme E2 variant 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon in the 5' coding region and lacks an exon in the 3' coding region compred to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL589870
      Consensus CDS
      CCDS79869.1
      UniProtKB/Swiss-Prot
      Q9CZY3
      Related
      ENSMUSP00000053109.7, ENSMUST00000060645.13
      Conserved Domains (1) summary
      cl00154
      Location:16100
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_023230.2NP_075719.1  ubiquitin-conjugating enzyme E2 variant 1 isoform 2

      See identical proteins and their annotated locations for NP_075719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK158230
      Consensus CDS
      CCDS17103.1
      UniProtKB/Swiss-Prot
      Q9CZY3
      UniProtKB/TrEMBL
      Q569Y6
      Related
      ENSMUSP00000104830.4, ENSMUST00000109207.10
      Conserved Domains (1) summary
      smart00212
      Location:16142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      167449559..167473933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500014.5XP_006500077.1  ubiquitin-conjugating enzyme E2 variant 1 isoform X1

      Conserved Domains (1) summary
      cl00154
      Location:42126
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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