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    Cmpk1 cytidine monophosphate (UMP-CMP) kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66588, updated on 22-Aug-2021

    Summary

    Official Symbol
    Cmpk1provided by MGI
    Official Full Name
    cytidine monophosphate (UMP-CMP) kinase 1provided by MGI
    Primary source
    MGI:MGI:1913838
    See related
    Ensembl:ENSMUSG00000028719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK; Cmp; Cmpk; UMP-CMPk; 0610011D08Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 43.9), colon adult (RPKM 37.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Cmpk1 in Genome Data Viewer
    Location:
    4; 4 D1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114817810..114844425, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (114960613..114987228, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (114633218..114659833, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene forkhead box E3 Neighboring gene predicted gene, 40229 Neighboring gene Scl/Tal1 interrupting locus Neighboring gene predicted gene, 52674

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables CMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables UMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables UMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables cytidylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside monophosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables uridylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in CDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in CDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in UDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in UDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in dCDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dUDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleoside diphosphate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleoside triphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    UMP-CMP kinase
    Names
    UMP/CMPK
    cytidine monophosphate kinase
    cytidylate kinase 1
    dCMP kinase
    deoxycytidylate kinase
    likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK)
    nucleoside-diphosphate kinase
    uridine monophosphate kinase
    uridine monophosphate/cytidine monophosphate kinase
    NP_079923.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025647.3NP_079923.3  UMP-CMP kinase

      See identical proteins and their annotated locations for NP_079923.3

      Status: VALIDATED

      Source sequence(s)
      AK002526, AK077534, AK150162, AV315242
      Consensus CDS
      CCDS18484.1
      UniProtKB/Swiss-Prot
      Q9DBP5
      UniProtKB/TrEMBL
      A0A0R4J093
      Related
      ENSMUSP00000030491.9, ENSMUST00000030491.9
      Conserved Domains (2) summary
      cd01428
      Location:36215
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01359
      Location:36224
      UMP_CMP_kin_fam; UMP-CMP kinase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      114817810..114844425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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