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    Snrnp40 small nuclear ribonucleoprotein 40 (U5) [ Mus musculus (house mouse) ]

    Gene ID: 66585, updated on 23-Jun-2021

    Summary

    Official Symbol
    Snrnp40provided by MGI
    Official Full Name
    small nuclear ribonucleoprotein 40 (U5)provided by MGI
    Primary source
    MGI:MGI:1913835
    See related
    Ensembl:ENSMUSG00000074088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr5; Wdr57; Prp8bp; 0610009C03Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 42.3), limb E14.5 (RPKM 31.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Snrnp40 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130253925..130283826)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130360132..130390033)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (130037379..130067281)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 3, muscle and heart Neighboring gene zinc finger, CCHC domain containing 17 Neighboring gene predicted gene, 35074 Neighboring gene Na+/K+ transporting ATPase interacting 1 Neighboring gene predicted gene, 53228

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    U5 small nuclear ribonucleoprotein 40 kDa protein
    Names
    U5 snRNP 40 kDa protein
    U5 snRNP-specific protein (Prp8-binding)
    WD repeat domain 57 (U5 snRNP specific)
    WD repeat-containing protein 57
    small nuclear ribonucleoprotein 40kDa (U5)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025645.2NP_079921.2  U5 small nuclear ribonucleoprotein 40 kDa protein

      See identical proteins and their annotated locations for NP_079921.2

      Status: VALIDATED

      Source sequence(s)
      BC058365, BY002298, BY783206
      Consensus CDS
      CCDS38892.1
      UniProtKB/Swiss-Prot
      Q6PE01
      Related
      ENSMUSP00000101616.4, ENSMUST00000105994.4
      Conserved Domains (2) summary
      cd00200
      Location:63352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:71108
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130253925..130283826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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