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    Cenpm centromere protein M [ Mus musculus (house mouse) ]

    Gene ID: 66570, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cenpmprovided by MGI
    Official Full Name
    centromere protein Mprovided by MGI
    Primary source
    MGI:MGI:1913820
    See related
    Ensembl:ENSMUSG00000068101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pane1; AI853711; 2610019I03Rik
    Summary
    This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.4), thymus adult (RPKM 7.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See Cenpm in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (82233762..82244772, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (82064192..82075177, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene shisa family member 8 Neighboring gene tumor necrosis factor receptor superfamily, member 13c Neighboring gene RIKEN cDNA 1500009C09 gene Neighboring gene septin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centromere protein M
    Names
    CENP-M
    proliferation associated nuclear element 1
    proliferation-associated nuclear element protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080158.1NP_001073627.1  centromere protein M isoform 3

      See identical proteins and their annotated locations for NP_001073627.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI853711, AK011227, BG276334
      UniProtKB/Swiss-Prot
      Q9CQA0
      Conserved Domains (1) summary
      pfam11111
      Location:1138
      CENP-M; Centromere protein M (CENP-M)
    2. NM_025639.4NP_079915.1  centromere protein M isoform 1

      See identical proteins and their annotated locations for NP_079915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI853711, AK011227, BY710734
      Consensus CDS
      CCDS27685.1
      UniProtKB/Swiss-Prot
      Q9CQA0
      Related
      ENSMUSP00000086560.3, ENSMUST00000089157.10
      Conserved Domains (1) summary
      pfam11111
      Location:1172
      CENP-M; Centromere protein M (CENP-M)
    3. NM_178269.3NP_840000.2  centromere protein M isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI853711, AK011227, BY710734
      Consensus CDS
      CCDS37156.1
      UniProtKB/Swiss-Prot
      Q9CQA0
      Related
      ENSMUSP00000086558.4, ENSMUST00000089155.5
      Conserved Domains (1) summary
      pfam11111
      Location:1110
      CENP-M; Centromere protein M (CENP-M)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      82233762..82244772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316722.1XP_017172211.1  centromere protein M isoform X2

    2. XM_006521260.3XP_006521323.1  centromere protein M isoform X3

      See identical proteins and their annotated locations for XP_006521323.1

      Conserved Domains (1) summary
      pfam11111
      Location:1138
      CENP-M; Centromere protein M (CENP-M)
    3. XM_011245710.2XP_011244012.1  centromere protein M isoform X1

      Conserved Domains (1) summary
      pfam11111
      Location:1134
      CENP-M; Centromere protein M (CENP-M)
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