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    Drap1 Dr1 associated protein 1 (negative cofactor 2 alpha) [ Mus musculus (house mouse) ]

    Gene ID: 66556, updated on 23-Jun-2021

    Summary

    Official Symbol
    Drap1provided by MGI
    Official Full Name
    Dr1 associated protein 1 (negative cofactor 2 alpha)provided by MGI
    Primary source
    MGI:MGI:1913806
    See related
    Ensembl:ENSMUSG00000024914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NC2-alpha; 2310074H19Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 92.7), CNS E11.5 (RPKM 65.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Drap1 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5472832..5475007, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5422804..5424979, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5422811..5424916, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54050 Neighboring gene RIKEN cDNA 4930481A15 gene Neighboring gene predicted pseudogene 6293 Neighboring gene expressed sequence AI837181 Neighboring gene predicted gene, 25432

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of negative cofactor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291080.1NP_001278009.1  dr1-associated corepressor isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122861, AK087456
      Consensus CDS
      CCDS70919.1
      UniProtKB/Swiss-Prot
      Q9D6N5
      UniProtKB/TrEMBL
      D3YY09
      Related
      ENSMUSP00000109304.2, ENSMUST00000113674.8
      Conserved Domains (1) summary
      pfam00808
      Location:1174
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    2. NM_024176.2NP_077138.1  dr1-associated corepressor isoform 2

      See identical proteins and their annotated locations for NP_077138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC122861, AK087456
      Consensus CDS
      CCDS29462.1
      UniProtKB/Swiss-Prot
      Q9D6N5
      UniProtKB/TrEMBL
      Q4FJW2
      Related
      ENSMUSP00000025853.10, ENSMUST00000025853.16
      Conserved Domains (1) summary
      pfam00808
      Location:1174
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5472832..5475007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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