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    Rnf181 ring finger protein 181 [ Mus musculus (house mouse) ]

    Gene ID: 66510, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf181provided by MGI
    Official Full Name
    ring finger protein 181provided by MGI
    Primary source
    MGI:MGI:1913760
    See related
    Ensembl:ENSMUSG00000055850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C77350; 1700047F16Rik; 2500002L14Rik; 6230415N01Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 73.1), adrenal adult (RPKM 55.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rnf181 in Genome Data Viewer
    Location:
    6; 6 C1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72336695..72343977, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72359712..72366994, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (72309708..72312375, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 39 Neighboring gene RIKEN cDNA 0610030E20 gene Neighboring gene transmembrane protein 150A Neighboring gene vesicle-associated membrane protein 5 Neighboring gene predicted gene, 52494 Neighboring gene vesicle-associated membrane protein 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103058

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF181
    Names
    RING-type E3 ubiquitin transferase RNF181
    NP_001318096.1
    NP_001318097.1
    NP_001318098.1
    NP_001318099.1
    NP_001318100.1
    NP_001318101.1
    NP_001318102.1
    NP_079883.3
    XP_030111400.1
    XP_030111401.1
    XP_030111402.1
    XP_030111403.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331167.1NP_001318096.1  E3 ubiquitin-protein ligase RNF181 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA154118, AC116115, AK018849, AK166904, BY086964
      Consensus CDS
      CCDS85064.1
      UniProtKB/Swiss-Prot
      Q9CY62
      Related
      ENSMUSP00000138327.2, ENSMUST00000154098.3
      Conserved Domains (1) summary
      cd16669
      Location:4085
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
    2. NM_001331168.1NP_001318097.1  E3 ubiquitin-protein ligase RNF181 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK014094, BY772494
      Consensus CDS
      CCDS90058.1
      UniProtKB/Swiss-Prot
      Q9CY62
      Related
      ENSMUSP00000070370.7, ENSMUST00000069595.13
    3. NM_001331169.1NP_001318098.1  E3 ubiquitin-protein ligase RNF181 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK166904, BY772494, CK387918
      Consensus CDS
      CCDS85064.1
      UniProtKB/Swiss-Prot
      Q9CY62
      Conserved Domains (1) summary
      cd16669
      Location:4085
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
    4. NM_001331170.1NP_001318099.1  E3 ubiquitin-protein ligase RNF181 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116115
    5. NM_001331171.1NP_001318100.1  E3 ubiquitin-protein ligase RNF181 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116115
      Consensus CDS
      CCDS90057.1
      UniProtKB/TrEMBL
      D3YUJ1
      Related
      ENSMUSP00000109729.2, ENSMUST00000114095.2
    6. NM_001331172.1NP_001318101.1  E3 ubiquitin-protein ligase RNF181 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116115
    7. NM_001331173.1NP_001318102.1  E3 ubiquitin-protein ligase RNF181 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116115
    8. NM_025607.4NP_079883.3  E3 ubiquitin-protein ligase RNF181 isoform 1

      See identical proteins and their annotated locations for NP_079883.3

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK166904, BY772494
      Consensus CDS
      CCDS20240.1
      UniProtKB/Swiss-Prot
      Q9CY62
      Related
      ENSMUSP00000066128.6, ENSMUST00000069580.12
      Conserved Domains (1) summary
      cd16669
      Location:87132
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    RNA

    1. NR_138579.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA154118, AC116115, AK166904, BB851224, BY772494
    2. NR_138580.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA154118, AK166904, BY772494, DV652726
    3. NR_138581.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116115
      Related
      ENSMUST00000125554.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72336695..72343977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255540.1XP_030111400.1  E3 ubiquitin-protein ligase RNF181 isoform X1

      Conserved Domains (1) summary
      cd16669
      Location:87132
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
    2. XM_030255542.1XP_030111402.1  E3 ubiquitin-protein ligase RNF181 isoform X2

      Conserved Domains (1) summary
      cd16669
      Location:4085
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
    3. XM_030255541.2XP_030111401.1  E3 ubiquitin-protein ligase RNF181 isoform X1

      Conserved Domains (1) summary
      cd16669
      Location:87132
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
    4. XM_030255543.1XP_030111403.1  E3 ubiquitin-protein ligase RNF181 isoform X2

      Conserved Domains (1) summary
      cd16669
      Location:4085
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
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