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    BNIP3L BCL2 interacting protein 3 like [ Homo sapiens (human) ]

    Gene ID: 665, updated on 5-Mar-2024

    Summary

    Official Symbol
    BNIP3Lprovided by HGNC
    Official Full Name
    BCL2 interacting protein 3 likeprovided by HGNC
    Primary source
    HGNC:HGNC:1085
    See related
    Ensembl:ENSG00000104765 MIM:605368; AllianceGenome:HGNC:1085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIX; NIP3L; BNIP3a
    Summary
    This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in fat (RPKM 69.4), ovary (RPKM 49.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BNIP3L in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (26383054..26413127)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (26659614..26689692)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26240570..26270643)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19038 Neighboring gene protein phosphatase 2 regulatory subunit Balpha Neighboring gene Sharpr-MPRA regulatory region 13890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26192157-26192656 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:26239047-26240246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19039 Neighboring gene Sharpr-MPRA regulatory region 12075 Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene GATA motif-containing MPRA enhancer 260 Neighboring gene Sharpr-MPRA regulatory region 1267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27127 Neighboring gene DNAJB6 pseudogene 2 Neighboring gene vegetative cell wall protein gp1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19042

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lamin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lamin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
    Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
    BCL2/adenovirus E1B 19-kd protein-interacting protein 3a
    BCL2/adenovirus E1B 19kDa interacting protein 3 like
    NIP-3-like protein X
    NIP3-like protein X
    adenovirus E1B19k-binding protein B5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330491.2NP_001317420.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011726, AK316315, BG942896
      Consensus CDS
      CCDS83267.1
      UniProtKB/TrEMBL
      H0YBC7
      Related
      ENSP00000429851.1, ENST00000518611.5
      Conserved Domains (1) summary
      pfam06553
      Location:17178
      BNIP3
    2. NM_004331.3NP_004322.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

      See identical proteins and their annotated locations for NP_004322.1

      Status: REVIEWED

      Source sequence(s)
      AA946755, AB004788, AF536326, AL132665, BF337139, BQ719112, CD244492, CD558918
      Consensus CDS
      CCDS6050.1
      UniProtKB/Swiss-Prot
      B0AZS9, O60238, Q5JW63, Q8NF87
      UniProtKB/TrEMBL
      Q6IBV1, Q9H3K3
      Related
      ENSP00000370003.2, ENST00000380629.7
      Conserved Domains (1) summary
      pfam06553
      Location:28218
      BNIP3; BNIP3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      26383054..26413127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      26659614..26689692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)