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    Dda1 DET1 and DDB1 associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 66498, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dda1provided by MGI
    Official Full Name
    DET1 and DDB1 associated 1provided by MGI
    Primary source
    MGI:MGI:1913748
    See related
    Ensembl:ENSMUSG00000074247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R74921; 1500034J01Rik; 1700095J19Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 57.3), adrenal adult (RPKM 55.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dda1 in Genome Data Viewer
    Location:
    8; 8 B3.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71921816..71928743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71469172..71476099)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (73993093..74000334)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene anoctamin 8 Neighboring gene GTP binding protein 3 Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DET1- and DDB1-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294258.1NP_001281187.1  DET1- and DDB1-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA036394, AC127416, AK032966, BY316490
      Consensus CDS
      CCDS80894.1
      UniProtKB/Swiss-Prot
      Q9D9Z5
      UniProtKB/TrEMBL
      D3YXY5
      Related
      ENSMUSP00000123665.2, ENSMUST00000147642.2
      Conserved Domains (1) summary
      pfam10172
      Location:346
      DDA1; Det1 complexing ubiquitin ligase
    2. NM_001294259.1NP_001281188.1  DET1- and DDB1-associated protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC127416, AK032966, BY297077, BY316490
      UniProtKB/Swiss-Prot
      Q9D9Z5
      Conserved Domains (1) summary
      pfam10172
      Location:238
      DDA1; Det1 complexing ubiquitin ligase
    3. NM_025600.2NP_079876.1  DET1- and DDB1-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_079876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC127416, AK032966, BB610194, BY316490
      Consensus CDS
      CCDS52584.1
      UniProtKB/Swiss-Prot
      Q9D9Z5
      Related
      ENSMUSP00000121042.2, ENSMUST00000124745.8
      Conserved Domains (1) summary
      pfam10172
      Location:365
      DDA1; Det1 complexing ubiquitin ligase

    RNA

    1. NR_122114.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC127416, AK032966, AK149117, BY316490
      Related
      ENSMUST00000130098.8
    2. NR_122115.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC127416, AK032966, AK149980, BY316490
      Related
      ENSMUST00000135052.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71921816..71928743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242317.2XP_011240619.1  DET1- and DDB1-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10172
      Location:4790
      DDA1; Det1 complexing ubiquitin ligase
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