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    Gtf2h5 general transcription factor IIH, polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 66467, updated on 8-Jul-2021

    Summary

    Official Symbol
    Gtf2h5provided by MGI
    Official Full Name
    general transcription factor IIH, polypeptide 5provided by MGI
    Primary source
    MGI:MGI:107227
    See related
    Ensembl:ENSMUSG00000034345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D17Wsu155; D17Wsu155e; 2700017P07Rik; 2810432H05Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 27.4), CNS E14 (RPKM 21.4) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Gtf2h5 in Genome Data Viewer
    Location:
    17 A1; 17 3.7 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6130103..6135763)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6079828..6085488)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (6079828..6085488)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 Neighboring gene predicted gene, 46591 Neighboring gene serine active site containing 1 Neighboring gene tubby like protein 4 Neighboring gene fibrillarin, pseudogene 2 Neighboring gene ferritin light chain 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair, preincision complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within nucleotide-excision repair, preincision complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within transcription elongation from RNA polymerase I promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription initiation from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    general transcription factor IIH subunit 5
    Names
    TFB5 ortholog
    TFIIH basal transcription factor complex TTD-A subunit
    TFIIH subunit p8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357804.1NP_001344733.1  general transcription factor IIH subunit 5

      Status: VALIDATED

      Source sequence(s)
      AC154650, AK012257, BM940130
      Consensus CDS
      CCDS37423.1
      Related
      ENSMUSP00000098515.3, ENSMUST00000100955.3
      Conserved Domains (1) summary
      pfam06331
      Location:169
      Tfb5; Transcription factor TFIIH complex subunit Tfb5
    2. NM_181392.3NP_852057.2  general transcription factor IIH subunit 5

      See identical proteins and their annotated locations for NP_852057.2

      Status: VALIDATED

      Source sequence(s)
      AK003547, AK013225, BM940130, W50582
      Consensus CDS
      CCDS37423.1
      UniProtKB/Swiss-Prot
      Q8K2X8
      Related
      ENSMUSP00000040355.4, ENSMUST00000039487.10
      Conserved Domains (1) summary
      pfam06331
      Location:169
      Tfb5; Transcription factor TFIIH complex subunit Tfb5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      6130103..6135763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523240.4XP_006523303.1  general transcription factor IIH subunit 5 isoform X1

      See identical proteins and their annotated locations for XP_006523303.1

      UniProtKB/Swiss-Prot
      Q8K2X8
      Conserved Domains (1) summary
      pfam06331
      Location:169
      Tfb5; Transcription factor TFIIH complex subunit Tfb5
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