U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Exosc7 exosome component 7 [ Mus musculus (house mouse) ]

    Gene ID: 66446, updated on 15-Nov-2022

    Summary

    Official Symbol
    Exosc7provided by MGI
    Official Full Name
    exosome component 7provided by MGI
    Primary source
    MGI:MGI:1913696
    See related
    Ensembl:ENSMUSG00000025785 AllianceGenome:MGI:1913696
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0116; 2610002K22Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA metabolic process. Predicted to act upstream of or within rRNA processing. Predicted to be located in cytoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in alimentary system; brain ventricular layer; liver; and metanephros. Orthologous to human EXOSC7 (exosome component 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.3), CNS E11.5 (RPKM 23.4) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Exosc7 in Genome Data Viewer
    Location:
    9; 9 F4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122942296..122965194)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123113231..123136129)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 42 Neighboring gene transglutaminase 4 (prostate) Neighboring gene zinc finger, DHHC domain containing 3 Neighboring gene C-type lectin domain family 3, member b Neighboring gene predicted gene, 23323

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exonucleolytic catabolism of deadenylated mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent tRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cytoplasmic exosome (RNase complex) IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exosome (RNase complex) IC
    Inferred by Curator
    more info
    PubMed 
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of nuclear exosome (RNase complex) IC
    Inferred by Curator
    more info
    PubMed 
    part_of nucleolar exosome (RNase complex) IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exosome complex exonuclease RRP42
    Names
    ribosomal RNA-processing protein 42

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081188.1NP_001074657.1  exosome complex exonuclease RRP42

      See identical proteins and their annotated locations for NP_001074657.1

      Status: PROVISIONAL

      Source sequence(s)
      AC134248
      Consensus CDS
      CCDS40815.1
      UniProtKB/Swiss-Prot
      Q9CT77, Q9D0M0
      UniProtKB/TrEMBL
      A0A8C6N0A9
      Related
      ENSMUSP00000026891.5, ENSMUST00000026891.5
      Conserved Domains (1) summary
      cd11367
      Location:5276
      RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122942296..122965194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512208.1XP_006512271.1  exosome complex exonuclease RRP42 isoform X2

      Conserved Domains (1) summary
      cl03114
      Location:18155
      RNase_PH; RNase PH-like 3'-5' exoribonucleases
    2. XM_006512207.5XP_006512270.1  exosome complex exonuclease RRP42 isoform X1

      See identical proteins and their annotated locations for XP_006512270.1

      Conserved Domains (1) summary
      cd11367
      Location:8198
      RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025568.1: Suppressed sequence

      Description
      NM_025568.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.