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    Magohb mago homolog B, exon junction complex core component [ Mus musculus (house mouse) ]

    Gene ID: 66441, updated on 26-Sep-2022

    Summary

    Official Symbol
    Magohbprovided by MGI
    Official Full Name
    mago homolog B, exon junction complex core componentprovided by MGI
    Primary source
    MGI:MGI:1913691
    See related
    Ensembl:ENSMUSG00000030188 AllianceGenome:MGI:1913691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mago; Magoh; Magoh-rs1; 2010012C16Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to act upstream of or within mRNA processing and mRNA transport. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of exon-exon junction complex and spliceosomal complex. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 7.8), liver E14 (RPKM 7.0) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Magohb in Genome Data Viewer
    Location:
    6 F3; 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (131261351..131270207, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (131284389..131293244, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor, subfamily A, member 2 Neighboring gene predicted gene 5582 Neighboring gene serine/threonine/tyrosine kinase 1 Neighboring gene Y box protein 3 Neighboring gene predicted gene, 22362

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA export from nucleus IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IC
    Inferred by Curator
    more info
    PubMed 
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exon-exon junction subcomplex mago-y14 ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein mago nashi homolog 2
    Names
    mago nashi protein
    mago-nashi homolog B
    mago-nashi homolog, proliferation-associated, related sequence 1
    protein mago nashi homolog 1-related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327860.1NP_001314789.1  protein mago nashi homolog 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, resulting in the use of a downstream in-frame translational start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK008200, BE649735
      Consensus CDS
      CCDS85172.1
      UniProtKB/Swiss-Prot
      Q9CQL1
      UniProtKB/TrEMBL
      A0A6P5PYW8, G3UZW7
      Related
      ENSMUSP00000134663.2, ENSMUST00000173837.6
      Conserved Domains (1) summary
      cl03715
      Location:1102
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
    2. NM_025564.2NP_079840.2  protein mago nashi homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_079840.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK008200
      Consensus CDS
      CCDS39670.2
      UniProtKB/Swiss-Prot
      Q9CQL1
      UniProtKB/TrEMBL
      A0A023T778, A0A6P5PW05, A0A8C6MSP7
      Related
      ENSMUSP00000032307.6, ENSMUST00000032307.12
      Conserved Domains (1) summary
      cd11295
      Location:6148
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      131261351..131270207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152262.1XP_036008155.1  protein mago nashi homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A6P5PYW8, G3UZW7
      Conserved Domains (1) summary
      cl03715
      Location:1102
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex