U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Cyb5b cytochrome b5 type B [ Mus musculus (house mouse) ]

    Gene ID: 66427, updated on 5-Jan-2023

    Summary

    Official Symbol
    Cyb5bprovided by MGI
    Official Full Name
    cytochrome b5 type Bprovided by MGI
    Primary source
    MGI:MGI:1913677
    See related
    Ensembl:ENSMUSG00000031924 AllianceGenome:MGI:1913677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyb5m; 1810044O22Rik
    Summary
    Predicted to enable enzyme activator activity and heme binding activity. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in nitric oxide biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including adrenal gland; craniocervical region bone; gut; neural retina; and urinary system. Orthologous to human CYB5B (cytochrome b5 type B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 115.2), genital fat pad adult (RPKM 95.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cyb5b in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107877293..107914102)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107150661..107187470)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene telomeric repeat binding factor 2 Neighboring gene microRNA 7075 Neighboring gene predicted gene, 39240 Neighboring gene RIKEN cDNA 4930517G24 gene Neighboring gene ribosomal protein S18, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to nitrite reductase (NO-forming) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025558.5NP_079834.2  cytochrome b5 type B precursor

      See identical proteins and their annotated locations for NP_079834.2

      Status: VALIDATED

      Source sequence(s)
      AC125207
      Consensus CDS
      CCDS22647.1
      UniProtKB/Swiss-Prot
      Q9CQX2, Q9D8R3
      UniProtKB/TrEMBL
      A0A8C6GGB9
      Related
      ENSMUSP00000034400.4, ENSMUST00000034400.5
      Conserved Domains (2) summary
      pfam00173
      Location:2295
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      cl00200
      Location:119139
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      107877293..107914102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)