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    Nudt2 nudix hydrolase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66401, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nudt2provided by MGI
    Official Full Name
    nudix hydrolase 2provided by MGI
    Primary source
    MGI:MGI:1913651
    See related
    Ensembl:ENSMUSG00000028443 AllianceGenome:MGI:1913651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APAH1; 2310051L06Rik
    Summary
    Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process; ATP biosynthetic process; and apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 14.1), placenta adult (RPKM 10.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nudt2 in Genome Data Viewer
    Location:
    4 A5; 4 21.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41465085..41480926)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41465081..41480926)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:41295845-41296146 Neighboring gene ubiquitin-associated protein 1 Neighboring gene kinesin family member 24 Neighboring gene STARR-seq mESC enhancer starr_10033 Neighboring gene STARR-positive B cell enhancer ABC_E277 Neighboring gene STARR-seq mESC enhancer starr_10034 Neighboring gene myogenesis regulating glycosidase (putative) Neighboring gene sperm microtubule inner protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ATP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
    Names
    ap4A hydrolase
    ap4Aase
    bis(5'-nucleosyl)-tetraphosphatase
    diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
    diadenosine tetraphosphatase
    nucleoside diphosphate-linked moiety X motif 2
    nudix (nucleoside diphosphate linked moiety X)-type motif 2
    nudix motif 2
    NP_079815.2
    XP_006538228.1
    XP_011248384.1
    XP_030109557.1
    XP_036020201.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025539.2NP_079815.2  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

      See identical proteins and their annotated locations for NP_079815.2

      Status: VALIDATED

      Source sequence(s)
      AK018771, AK132532, CB845734
      Consensus CDS
      CCDS18061.1
      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Related
      ENSMUSP00000030154.7, ENSMUST00000030154.7
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41465085..41480926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164308.1XP_036020201.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    2. XM_011250082.4XP_011248384.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      See identical proteins and their annotated locations for XP_011248384.1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    3. XM_030253697.2XP_030109557.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    4. XM_006538165.4XP_006538228.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

      See identical proteins and their annotated locations for XP_006538228.1

      UniProtKB/Swiss-Prot
      P56380, Q9D2U6, Q9D6V2
      UniProtKB/TrEMBL
      Q3V1C8
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...