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    Rtca RNA 3'-terminal phosphate cyclase [ Mus musculus (house mouse) ]

    Gene ID: 66368, updated on 31-Jan-2019

    Summary

    Official Symbol
    Rtcaprovided by MGI
    Official Full Name
    RNA 3'-terminal phosphate cyclaseprovided by MGI
    Primary source
    MGI:MGI:1913618
    See related
    Ensembl:ENSMUSG00000000339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPC; Rtcd1; AI450277; 2310009A18Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 35.2), CNS E11.5 (RPKM 29.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rtca in Genome Data Viewer
    Location:
    3; 3 G1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (116488963..116508203, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (116191881..116211093, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46839 Neighboring gene CDC14 cell division cycle 14A Neighboring gene predicted gene, 40125 Neighboring gene dihydrolipoamide branched chain transacylase E2 Neighboring gene ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) pseudogene Neighboring gene splicing factor, arginine/serine-rich pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102342

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA-3'-phosphate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA 3'-terminal phosphate cyclase
    Names
    RNA cyclase
    RNA terminal phosphate cyclase domain 1
    RNA terminal phosphate cyclase domain-containing protein 1
    RNA-3'-phosphate cyclase
    NP_079793.2
    XP_006501946.1
    XP_006501947.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025517.3NP_079793.2  RNA 3'-terminal phosphate cyclase

      See identical proteins and their annotated locations for NP_079793.2

      Status: VALIDATED

      Source sequence(s)
      AK152129, AK159961, BM899781
      Consensus CDS
      CCDS17786.1
      UniProtKB/Swiss-Prot
      Q9D7H3
      Related
      ENSMUSP00000000348.8, ENSMUST00000000348.14
      Conserved Domains (2) summary
      cd00874
      Location:8340
      RNA_Cyclase_Class_II; RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in ...
      pfam01137
      Location:12338
      RTC; RNA 3'-terminal phosphate cyclase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      116488963..116508203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501884.2XP_006501947.1  RNA 3'-terminal phosphate cyclase isoform X2

      See identical proteins and their annotated locations for XP_006501947.1

      Conserved Domains (2) summary
      cl00288
      Location:1234
      EPT_RTPC-like; This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a ...
      pfam01137
      Location:1232
      RTC; RNA 3'-terminal phosphate cyclase
    2. XM_006501883.1XP_006501946.1  RNA 3'-terminal phosphate cyclase isoform X1

      Conserved Domains (2) summary
      cl00288
      Location:1283
      EPT_RTPC-like; This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a ...
      pfam01137
      Location:1281
      RTC; RNA 3'-terminal phosphate cyclase

    RNA

    1. XR_001783733.1 RNA Sequence

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