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    Cenpw centromere protein W [ Mus musculus (house mouse) ]

    Gene ID: 66311, updated on 18-Sep-2024

    Summary

    Official Symbol
    Cenpwprovided by MGI
    Official Full Name
    centromere protein Wprovided by MGI
    Primary source
    MGI:MGI:1913561
    See related
    Ensembl:ENSMUSG00000075266 AllianceGenome:MGI:1913561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cug2; 2610036L11Rik
    Summary
    Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Predicted to act upstream of or within cell division. Predicted to be located in chromosome, centromeric region. Predicted to be active in kinetochore and nucleoplasm. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human CENPW (centromere protein W). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 9.7), CNS E11.5 (RPKM 8.7) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Cenpw in Genome Data Viewer
    Location:
    10 A4; 10 16.93 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30072005..30076599, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30196009..30200603, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26187 Neighboring gene aldolase 1 A retrogene 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26188 Neighboring gene STARR-seq mESC enhancer starr_26189 Neighboring gene STARR-seq mESC enhancer starr_26190 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26192 Neighboring gene STARR-seq mESC enhancer starr_26193 Neighboring gene STARR-seq mESC enhancer starr_26194 Neighboring gene STARR-seq mESC enhancer starr_26195 Neighboring gene makorin, ring finger protein, 2 pseudogene Neighboring gene predicted gene, 40622

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kinetochore assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    centromere protein W
    Names
    CENP-W
    cancer-up-regulated gene 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109747.1NP_001103217.1  centromere protein W

      See identical proteins and their annotated locations for NP_001103217.1

      Status: VALIDATED

      Source sequence(s)
      AK141272, BF453953, BG804382
      Consensus CDS
      CCDS35876.1
      UniProtKB/Swiss-Prot
      Q3URR0
      UniProtKB/TrEMBL
      A0A1L1SQB9, B2RVH1
      Related
      ENSMUSP00000097565.5, ENSMUST00000099985.6
      Conserved Domains (1) summary
      pfam15510
      Location:186
      CENP-W; Centromere kinetochore component W

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      30072005..30076599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512814.4XP_006512877.1  centromere protein W isoform X1

      Conserved Domains (1) summary
      pfam15510
      Location:140
      CENP-W; CENP-W protein