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    Atp6v1g1 ATPase, H+ transporting, lysosomal V1 subunit G1 [ Mus musculus (house mouse) ]

    Gene ID: 66290, updated on 26-Sep-2022

    Summary

    Official Symbol
    Atp6v1g1provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit G1provided by MGI
    Primary source
    MGI:MGI:1913540
    See related
    Ensembl:ENSMUSG00000039105 AllianceGenome:MGI:1913540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VAG1; ATP6J; Vma10; Atp6g1; 1810024D14Rik
    Summary
    Enables ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular iron ion homeostasis and cellular response to increased oxygen levels. Predicted to act upstream of or within ion transport. Located in cytosol; lysosomal membrane; and plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP6V1G1 (ATPase H+ transporting V1 subunit G1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 81.5), CNS E14 (RPKM 64.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atp6v1g1 in Genome Data Viewer
    Location:
    4; 4 B3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63463002..63468938)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63544765..63550701)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene AT-hook transcription factor Neighboring gene predicted gene, 52742 Neighboring gene whirlin Neighboring gene predicted gene, 38592 Neighboring gene transmembrane protein 268 Neighboring gene predicted gene, 24448 Neighboring gene testis expressed 53

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    V-type proton ATPase subunit G 1
    Names
    ATPase, H+ transporting, V1 subunit G
    ATPase, H+ transporting, lysosomal (vacuolar proton pump)
    ATPase, H+ transporting, lysosomal 13kD, V1 subunit G
    V-ATPase 13 kDa subunit 1
    V-ATPase subunit G 1
    lysosomal 13kDa
    vacuolar proton pump subunit G 1
    NP_077135.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024173.2NP_077135.1  V-type proton ATPase subunit G 1

      See identical proteins and their annotated locations for NP_077135.1

      Status: VALIDATED

      Source sequence(s)
      AI836426, AK007596, CN838691
      Consensus CDS
      CCDS18260.1
      UniProtKB/Swiss-Prot
      Q9CR51
      UniProtKB/TrEMBL
      A0A8C6IJ83, Q5HZY7
      Related
      ENSMUSP00000048770.7, ENSMUST00000035301.7
      Conserved Domains (1) summary
      TIGR01147
      Location:1113
      V_ATP_synt_G; vacuolar ATP synthase, subunit G

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63463002..63468938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)