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    Thoc7 THO complex 7 [ Mus musculus (house mouse) ]

    Gene ID: 66231, updated on 12-Aug-2018

    Summary

    Official Symbol
    Thoc7provided by MGI
    Official Full Name
    THO complex 7provided by MGI
    Primary source
    MGI:MGI:1913481
    See related
    Ensembl:ENSMUSG00000053453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nif3l1bp1
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.3), CNS E14 (RPKM 20.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Thoc7 in Genome Data Viewer
    Location:
    14; 14 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (13949012..13961847, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (14781528..14793739, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene 281 Neighboring gene zinc finger, AN1-type domain 5 pseudogene Neighboring gene predicted gene 11100 Neighboring gene ataxin 7 Neighboring gene predicted gene, 31222 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC151296, MGC151322, 1500006O09Rik, 9230101K24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    viral mRNA export from host cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    THO complex ISO
    Inferred from Sequence Orthology
    more info
     
    THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    THO complex subunit 7 homolog
    Names
    THO complex 7 homolog
    ngg1-interacting factor 3-like protein 1-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285780.1NP_001272709.1  THO complex subunit 7 homolog isoform 3

      See identical proteins and their annotated locations for NP_001272709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK147003, CF949442, CK329337
      UniProtKB/Swiss-Prot
      Q7TMY4
      Conserved Domains (2) summary
      pfam05615
      Location:187
      THOC7; Tho complex subunit 7
      cl25732
      Location:30147
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001359900.1NP_001346829.1  THO complex subunit 7 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC171681, AK147003, CF949442, CK329337
      Conserved Domains (2) summary
      pfam05615
      Location:187
      THOC7; Tho complex subunit 7
      cl25732
      Location:30147
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_001359901.1NP_001346830.1  THO complex subunit 7 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116479, AK005176, CF949442
      Conserved Domains (2) summary
      pfam05615
      Location:3135
      THOC7; Tho complex subunit 7
      cl25732
      Location:78195
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_025435.3NP_079711.1  THO complex subunit 7 homolog isoform 1

      See identical proteins and their annotated locations for NP_079711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK005176, CF949442, CK329337
      Consensus CDS
      CCDS49403.1
      UniProtKB/Swiss-Prot
      Q7TMY4
      Related
      ENSMUSP00000065819.8, ENSMUST00000065865.9
      Conserved Domains (1) summary
      pfam05615
      Location:7136
      THOC7; Tho complex subunit 7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      13949012..13961847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518076.3XP_006518139.1  THO complex subunit 7 homolog isoform X1

      Conserved Domains (1) summary
      pfam05615
      Location:66195
      THOC7; Tho complex subunit 7
    2. XM_006518077.3XP_006518140.1  THO complex subunit 7 homolog isoform X2

      UniProtKB/TrEMBL
      A0A286YCS0
      Related
      ENSMUSP00000153123.1, ENSMUST00000225325.1
      Conserved Domains (2) summary
      pfam05615
      Location:3135
      THOC7; Tho complex subunit 7
      cl25732
      Location:78195
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_017316120.1XP_017171609.1  THO complex subunit 7 homolog isoform X3

      Conserved Domains (2) summary
      pfam05615
      Location:187
      THOC7; Tho complex subunit 7
      cl25732
      Location:30147
      SMC_N; RecF/RecN/SMC N terminal domain
    4. XM_017316119.1XP_017171608.1  THO complex subunit 7 homolog isoform X3

      Conserved Domains (2) summary
      pfam05615
      Location:187
      THOC7; Tho complex subunit 7
      cl25732
      Location:30147
      SMC_N; RecF/RecN/SMC N terminal domain
    5. XM_006518078.3XP_006518141.1  THO complex subunit 7 homolog isoform X3

      See identical proteins and their annotated locations for XP_006518141.1

      Conserved Domains (2) summary
      pfam05615
      Location:187
      THOC7; Tho complex subunit 7
      cl25732
      Location:30147
      SMC_N; RecF/RecN/SMC N terminal domain
    6. XM_011244769.2XP_011243071.1  THO complex subunit 7 homolog isoform X3

      See identical proteins and their annotated locations for XP_011243071.1

      Conserved Domains (2) summary
      pfam05615
      Location:187
      THOC7; Tho complex subunit 7
      cl25732
      Location:30147
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. XR_382964.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013578.1: Suppressed sequence

      Description
      NM_001013578.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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