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    Llph LLP homolog, long-term synaptic facilitation (Aplysia) [ Mus musculus (house mouse) ]

    Gene ID: 66225, updated on 18-Sep-2024

    Summary

    Official Symbol
    Llphprovided by MGI
    Official Full Name
    LLP homolog, long-term synaptic facilitation (Aplysia)provided by MGI
    Primary source
    MGI:MGI:1913475
    See related
    Ensembl:ENSMUSG00000020224 AllianceGenome:MGI:1913475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190005P17Rik
    Summary
    Enables basal RNA polymerase II transcription machinery binding activity. Involved in dendrite extension and positive regulation of dendritic spine development. Located in nucleolus. Orthologous to human LLPH (LLP homolog, long-term synaptic facilitation factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 29.1), CNS E11.5 (RPKM 23.5) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Llph in Genome Data Viewer
    Location:
    10 D2; 10 67.94 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120062967..120067976)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120227048..120232071)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E8371 Neighboring gene STARR-positive B cell enhancer ABC_E8372 Neighboring gene predicted gene, 38500 Neighboring gene STARR-positive B cell enhancer ABC_E5193 Neighboring gene STARR-positive B cell enhancer ABC_E8373 Neighboring gene STARR-seq mESC enhancer starr_28059 Neighboring gene transmembrane BAX inhibitor motif containing 4 Neighboring gene predicted gene, 40782 Neighboring gene STARR-positive B cell enhancer ABC_E3923 Neighboring gene STARR-seq mESC enhancer starr_28060 Neighboring gene STARR-seq mESC enhancer starr_28061 Neighboring gene RIKEN cDNA 1700006J14 gene Neighboring gene RIKEN cDNA 9230105E05 gene Neighboring gene predicted gene, 40783 Neighboring gene high mobility group AT-hook 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Clone Names

    • MGC117871

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables basal RNA polymerase II transcription machinery binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables basal RNA polymerase II transcription machinery binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in dendrite extension IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417829.1NP_001404758.1  protein LLP homolog

      Status: VALIDATED

      Source sequence(s)
      AC144942
      UniProtKB/Swiss-Prot
      Q3KQP9, Q9D945
      Related
      ENSMUSP00000118254.3, ENSMUST00000130198.3
    2. NM_025431.3NP_079707.1  protein LLP homolog

      See identical proteins and their annotated locations for NP_079707.1

      Status: VALIDATED

      Source sequence(s)
      AC144942
      Consensus CDS
      CCDS24206.1
      UniProtKB/Swiss-Prot
      Q3KQP9, Q9D945
      Related
      ENSMUSP00000020444.9, ENSMUST00000020444.16
      Conserved Domains (1) summary
      pfam10169
      Location:3121
      Laps; Learning-associated protein

    RNA

    1. NR_184636.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC144942

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      120062967..120067976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)