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    Commd6 COMM domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 66200, updated on 31-Jan-2019

    Summary

    Official Symbol
    Commd6provided by MGI
    Official Full Name
    COMM domain containing 6provided by MGI
    Primary source
    MGI:MGI:1913450
    See related
    Ensembl:ENSMUSG00000075486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110059J08Rik; 1700063H17Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.4), placenta adult (RPKM 14.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Commd6 in Genome Data Viewer
    Location:
    14; 14 E2.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (101633766..101640471, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (102032983..102039688, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene heat shock protein 1 (chaperonin), pseudogene 5 Neighboring gene TBC1 domain family, member 4 Neighboring gene predicted gene, 34417 Neighboring gene ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) Neighboring gene HCLS1 associated X-1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    COMM domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033132.3NP_001028304.1  COMM domain-containing protein 6 isoform 1

      See identical proteins and their annotated locations for NP_001028304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BB577089, BC132261, CK128085
      Consensus CDS
      CCDS37000.1
      UniProtKB/Swiss-Prot
      Q3V4B5
      UniProtKB/TrEMBL
      B7ZNP2
      Related
      ENSMUSP00000097912.2, ENSMUST00000100339.8
      Conserved Domains (1) summary
      cl06336
      Location:885
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    2. NM_001168592.1NP_001162064.1  COMM domain-containing protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001162064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      BB577089, CK128085, CK621880
      Consensus CDS
      CCDS49557.1
      UniProtKB/TrEMBL
      B7ZNP3
      Related
      ENSMUSP00000131634.1, ENSMUST00000168587.2
      Conserved Domains (1) summary
      cl06336
      Location:881
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      101633766..101640471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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