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    Nop10 NOP10 ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 66181, updated on 26-Sep-2022

    Summary

    Official Symbol
    Nop10provided by MGI
    Official Full Name
    NOP10 ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:1913431
    See related
    Ensembl:ENSMUSG00000027133 AllianceGenome:MGI:1913431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nola3; NOP10P; 1110036B12Rik
    Summary
    Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Predicted to be involved in snRNA pseudouridine synthesis; snoRNA guided rRNA pseudouridine synthesis; and telomere maintenance via telomerase. Predicted to act upstream of or within rRNA processing. Predicted to be located in nuclear body. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 87.2), liver E14.5 (RPKM 82.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nop10 in Genome Data Viewer
    Location:
    2; 2 E3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112092271..112093243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112261926..112262898)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52523 Neighboring gene lysophosphatidylcholine acyltransferase 4 Neighboring gene NUT midline carcinoma, family member 1 Neighboring gene solute carrier family 12, member 6 Neighboring gene predicted gene, 39908 Neighboring gene ER membrane protein complex subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables box H/ACA snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in snoRNA guided rRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase IC
    Inferred by Curator
    more info
    PubMed 
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of box H/ACA snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of box H/ACA telomerase RNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of box H/ACA telomerase RNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of telomerase holoenzyme complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    H/ACA ribonucleoprotein complex subunit 3
    Names
    H/ACA small nucleolar RNPs
    NOP10 ribonucleoprotein homolog
    nucleolar protein 10
    nucleolar protein family A, member 3
    snoRNP protein NOP10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025403.4NP_079679.1  H/ACA ribonucleoprotein complex subunit 3

      See identical proteins and their annotated locations for NP_079679.1

      Status: VALIDATED

      Source sequence(s)
      AK004120, AK012875
      Consensus CDS
      CCDS38198.1
      UniProtKB/Swiss-Prot
      Q9CQS2
      UniProtKB/TrEMBL
      A0A6P5PD29, A0A8C6MS82
      Related
      ENSMUSP00000028553.4, ENSMUST00000028553.4
      Conserved Domains (1) summary
      pfam04135
      Location:452
      Nop10p; Nucleolar RNA-binding protein, Nop10p family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      112092271..112093243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)