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    Nip7 NIP7, nucleolar pre-rRNA processing protein [ Mus musculus (house mouse) ]

    Gene ID: 66164, updated on 5-Aug-2018

    Summary

    Official Symbol
    Nip7provided by MGI
    Official Full Name
    NIP7, nucleolar pre-rRNA processing proteinprovided by MGI
    Primary source
    MGI:MGI:1913414
    See related
    Ensembl:ENSMUSG00000031917 Vega:OTTMUSG00000061931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEachy; AA408773; AA410017; 1110017C15Rik; 6330509M23Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.3), placenta adult (RPKM 13.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nip7 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (107056877..107060931)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (109580777..109584831)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene peptide deformylase (mitochondrial) Neighboring gene component of oligomeric golgi complex 8 Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene telomeric repeat binding factor 2 Neighboring gene 40S ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    60S ribosome subunit biogenesis protein NIP7 homolog
    Names
    kDa93
    nuclear import 7 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164472.1NP_001157944.1  60S ribosome subunit biogenesis protein NIP7 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC123868
      Consensus CDS
      CCDS52665.1
      UniProtKB/TrEMBL
      E9Q109
      Related
      ENSMUSP00000126153.1, OTTMUSP00000078381, ENSMUST00000170962.2, OTTMUST00000151141
      Conserved Domains (1) summary
      cl00607
      Location:1129
      PUA; PUA domain
    2. NM_025391.2NP_079667.2  60S ribosome subunit biogenesis protein NIP7 homolog isoform 1

      See identical proteins and their annotated locations for NP_079667.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC123868, AK003739, AK014290
      Consensus CDS
      CCDS22644.1
      UniProtKB/Swiss-Prot
      Q9CXK8
      Related
      ENSMUSP00000034392.5, OTTMUSP00000078380, ENSMUST00000034392.12, OTTMUST00000151140
      Conserved Domains (1) summary
      COG1374
      Location:1176
      NIP7; Rbosome biogenesis protein Nip4, contains PUA domain [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_028367.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an additional segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123868, BE623972

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      107056877..107060931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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