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    Bola2 bolA family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 66162, updated on 18-Sep-2024

    Summary

    Official Symbol
    Bola2provided by MGI
    Official Full Name
    bolA family member 2provided by MGI
    Primary source
    MGI:MGI:1913412
    See related
    Ensembl:ENSMUSG00000047721 AllianceGenome:MGI:1913412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BolA-2; 1110025L05Rik
    Summary
    Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in cellular iron ion homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including BOLA2B (bolA family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 95.2), colon adult (RPKM 53.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Bola2 in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126295172..126295865)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126696000..126696693)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6601 Neighboring gene SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E3751 Neighboring gene STARR-positive B cell enhancer ABC_E2252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133845996-133846179 Neighboring gene coronin, actin binding protein 1A Neighboring gene STARR-positive B cell enhancer ABC_E10475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133851295-133851448 Neighboring gene U1 small nuclear ribonucleoprotein 1C, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of iron-sulfur cluster assembly complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    bolA-like protein 2
    Names
    bolA-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175103.3NP_780312.1  bolA-like protein 2

      See identical proteins and their annotated locations for NP_780312.1

      Status: VALIDATED

      Source sequence(s)
      AK003922
      Consensus CDS
      CCDS40129.1
      UniProtKB/Swiss-Prot
      Q0P601, Q8BGS2
      Related
      ENSMUSP00000114873.2, ENSMUST00000130498.2
      Conserved Domains (1) summary
      pfam01722
      Location:1279
      BolA; BolA-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126295172..126295865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)