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    Ufc1 ubiquitin-fold modifier conjugating enzyme 1 [ Mus musculus (house mouse) ]

    Gene ID: 66155, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ufc1provided by MGI
    Official Full Name
    ubiquitin-fold modifier conjugating enzyme 1provided by MGI
    Primary source
    MGI:MGI:1913405
    See related
    Ensembl:ENSMUSG00000062963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM2; ESTM29; AA062310; 1110021H02Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 26.0), placenta adult (RPKM 25.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ufc1 in Genome Data Viewer
    Location:
    1 H3; 1 79.31 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171116137..171122575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171288564..171295002, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173218695..173225113, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin specific peptidase 21 Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene predicted gene, 25151

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UFM1 conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables UFM1 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K69-linked ufmylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K69-linked ufmylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reticulophagy ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-fold modifier-conjugating enzyme 1
    Names
    Ufm1-conjugating enzyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360931.1NP_001347860.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15488.1
      Related
      ENSMUSP00000106933.4, ENSMUST00000111302.4
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    2. NM_001360932.1NP_001347861.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229, AI596556, BE652094
      Consensus CDS
      CCDS15488.1
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    3. NM_001360933.1NP_001347862.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087229, AI596556
      Conserved Domains (1) summary
      pfam08694
      Location:680
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    4. NM_025388.3NP_079664.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

      See identical proteins and their annotated locations for NP_079664.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC087229, AK003897
      Consensus CDS
      CCDS15488.1
      UniProtKB/Swiss-Prot
      Q9CR09
      Related
      ENSMUSP00000078914.3, ENSMUST00000080001.9
      Conserved Domains (1) summary
      pfam08694
      Location:6160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171116137..171122575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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