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    Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 [ Mus musculus (house mouse) ]

    Gene ID: 66148, updated on 18-Sep-2024

    Summary

    Official Symbol
    Dnajc15provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C15provided by MGI
    Primary source
    MGI:MGI:1913398
    See related
    Ensembl:ENSMUSG00000022013 AllianceGenome:MGI:1913398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCJ; Dnajd1; 1110003P16Rik
    Summary
    Predicted to enable ATPase activator activity. Acts upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Located in mitochondrial inner membrane. Is expressed in endocrine gland; genitourinary system; heart; and nervous system. Orthologous to human DNAJC15 (DnaJ heat shock protein family (Hsp40) member C15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 177.3), ovary adult (RPKM 65.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Dnajc15 in Genome Data Viewer
    Location:
    14 D3; 14 41.04 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (78063657..78112357, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77826217..77874917, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37215 Neighboring gene predicted gene, 30467 Neighboring gene predicted gene 1587 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:78261113-78261296 Neighboring gene epithelial stromal interaction 1 Neighboring gene STARR-seq mESC enhancer starr_37217 Neighboring gene family with sequence similarity 216, member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PAM complex, Tim23 associated import motor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 15
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 15
    DnaJ (Hsp40) homolog, subfamily D, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025384.3NP_079660.1  dnaJ homolog subfamily C member 15

      See identical proteins and their annotated locations for NP_079660.1

      Status: PROVISIONAL

      Source sequence(s)
      BC027509
      Consensus CDS
      CCDS27292.1
      UniProtKB/Swiss-Prot
      Q78YY6
      Related
      ENSMUSP00000154390.2, ENSMUST00000226459.2
      Conserved Domains (1) summary
      cl02542
      Location:85142
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      78063657..78112357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)