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    Maco1 macoilin 1 [ Mus musculus (house mouse) ]

    Gene ID: 66146, updated on 23-Jun-2021

    Summary

    Official Symbol
    Maco1provided by MGI
    Official Full Name
    macoilin 1provided by MGI
    Primary source
    MGI:MGI:1913396
    See related
    Ensembl:ENSMUSG00000028826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C61; Tmem57; AI317300; AI606104; 1110007C24Rik; 9230118A01Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.9), CNS E18 (RPKM 14.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Maco1 in Genome Data Viewer
    Location:
    4 D3; 4 67.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134530070..134581242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134802759..134853931, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (134358674..134409260, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 1C, member 1 Neighboring gene predicted gene, 42326 Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene Rh blood group, D antigen Neighboring gene transmembrane protein 50A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuronal signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuronal signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in rough endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    macoilin
    Names
    brain-specific adapter protein C61
    brain-specific adaptor protein C61
    transmembrane protein 57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355499.1NP_001342428.1  macoilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK038972, AY846873
      Conserved Domains (1) summary
      pfam09726
      Location:19606
      Macoilin; Transmembrane protein
    2. NM_001355500.1NP_001342429.1  macoilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AY846873
      Conserved Domains (1) summary
      pfam09726
      Location:1485
      Macoilin; Transmembrane protein
    3. NM_001355501.1NP_001342430.1  macoilin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AY846873
      Conserved Domains (1) summary
      pfam09726
      Location:1485
      Macoilin; Transmembrane protein
    4. NM_025382.6NP_079658.2  macoilin isoform 1

      See identical proteins and their annotated locations for NP_079658.2

      Status: VALIDATED

      Source sequence(s)
      AY846873
      Consensus CDS
      CCDS18777.1
      UniProtKB/Swiss-Prot
      Q7TQE6
      Related
      ENSMUSP00000030628.8, ENSMUST00000030628.15
      Conserved Domains (3) summary
      TIGR03462
      Location:29113
      CarR_dom_SF; lycopene cyclase domain
      pfam09726
      Location:2662
      Macoilin; Transmembrane protein
      pfam16331
      Location:386462
      TolA_bind_tri; TolA binding protein trimerization

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134530070..134581242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164305.1XP_036020198.1  macoilin isoform X2

      Conserved Domains (1) summary
      pfam09726
      Location:1238
      Macoilin; Macoilin family
    2. XM_006539100.4XP_006539163.1  macoilin isoform X1

      Conserved Domains (1) summary
      pfam09726
      Location:2384
      Macoilin; Macoilin family

    RNA

    1. XR_004941943.1 RNA Sequence

    2. XR_001784176.2 RNA Sequence

    3. XR_004941944.1 RNA Sequence

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