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    Tipin timeless interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 66131, updated on 5-Aug-2018

    Summary

    Official Symbol
    Tipinprovided by MGI
    Official Full Name
    timeless interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1921571
    See related
    Ensembl:ENSMUSG00000032397 Vega:OTTMUSG00000062594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110005A05Rik; 1110018P21Rik
    Summary
    The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in liver E14 (RPKM 28.2), CNS E11.5 (RPKM 20.3) and 13 other tissues See more
    Orthologs

    Genomic context

    See Tipin in Genome Data Viewer
    Location:
    9 C; 9 34.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (64281491..64305422)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (64129414..64152599)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene multiple EGF-like-domains 11 Neighboring gene predicted gene, 36311

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA replication checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA replication checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    intra-S DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    replication fork protection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    TIMELESS-interacting protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324556.1NP_001311485.1  TIMELESS-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK038111, BF463598, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1
      Conserved Domains (1) summary
      pfam07962
      Location:65143
      Swi3; Replication Fork Protection Component Swi3
    2. NM_001324557.1NP_001311486.1  TIMELESS-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK011357, AK038111, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1
      Conserved Domains (1) summary
      pfam07962
      Location:65143
      Swi3; Replication Fork Protection Component Swi3
    3. NM_001324558.1NP_001311487.1  TIMELESS-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK038111, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1
      Related
      ENSMUSP00000149833.1, OTTMUSP00000079032, ENSMUST00000216594.1, OTTMUST00000152464
      Conserved Domains (1) summary
      pfam07962
      Location:65143
      Swi3; Replication Fork Protection Component Swi3
    4. NM_025372.4NP_079648.1  TIMELESS-interacting protein

      See identical proteins and their annotated locations for NP_079648.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK003802, AK038111, CJ082457
      Consensus CDS
      CCDS23279.1
      UniProtKB/Swiss-Prot
      Q91WA1
      Related
      ENSMUSP00000034964.6, ENSMUST00000034964.6
      Conserved Domains (1) summary
      pfam07962
      Location:65143
      Swi3; Replication Fork Protection Component Swi3

    RNA

    1. NR_136926.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK038111, CA321902, CJ082457

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      64281491..64305422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511340.3XP_006511403.1  TIMELESS-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006511403.1

      UniProtKB/Swiss-Prot
      Q91WA1
      Conserved Domains (1) summary
      pfam07962
      Location:65143
      Swi3; Replication Fork Protection Component Swi3

    RNA

    1. XR_001778960.1 RNA Sequence

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