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    Rmnd5b required for meiotic nuclear division 5 homolog B [ Mus musculus (house mouse) ]

    Gene ID: 66089, updated on 26-Sep-2022

    Summary

    Official Symbol
    Rmnd5bprovided by MGI
    Official Full Name
    required for meiotic nuclear division 5 homolog Bprovided by MGI
    Primary source
    MGI:MGI:1913339
    See related
    Ensembl:ENSMUSG00000001054 AllianceGenome:MGI:1913339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid2; 0610039K22Rik
    Summary
    Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5B (required for meiotic nuclear division 5 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 67.7), adrenal adult (RPKM 44.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rmnd5b in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51514500..51526723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51623673..51635896, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene NHP2 ribonucleoprotein Neighboring gene predicted gene, 30058 Neighboring gene NEDD4 binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein transferase RMND5B
    Names
    protein RMD5 homolog B
    NP_079622.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025346.1NP_079622.1  E3 ubiquitin-protein transferase RMND5B

      See identical proteins and their annotated locations for NP_079622.1

      Status: PROVISIONAL

      Source sequence(s)
      AK075599
      Consensus CDS
      CCDS24656.1
      UniProtKB/Swiss-Prot
      Q91YQ7
      Related
      ENSMUSP00000001081.4, ENSMUST00000001081.10
      Conserved Domains (5) summary
      smart00667
      Location:116148
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:156212
      CTLH; C-terminal to LisH motif
      smart00757
      Location:210304
      CRA; CT11-RanBPM
      pfam10607
      Location:155299
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      pfam13445
      Location:338377
      zf-RING_UBOX; RING-type zinc-finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51514500..51526723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)