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    Emc3 ER membrane protein complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 66087, updated on 5-Mar-2024


    Official Symbol
    Emc3provided by MGI
    Official Full Name
    ER membrane protein complex subunit 3provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000030286 AllianceGenome:MGI:1913337
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pob; Tmem111; 0610039A15Rik
    Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in lung. Orthologous to human EMC3 (ER membrane protein complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in bladder adult (RPKM 30.4), subcutaneous fat pad adult (RPKM 27.8) and 28 other tissues See more
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    Genomic context

    6 E3; 6 52.78 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113491848..113508599, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113514887..113531638, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E684 Neighboring gene STARR-seq mESC enhancer starr_17041 Neighboring gene cysteine-rich with EGF-like domains 1 Neighboring gene proline-rich transmembrane protein 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113467707-113467969 Neighboring gene Fanconi anemia, complementation group D2 Neighboring gene STARR-seq mESC enhancer starr_17043 Neighboring gene predicted gene, 46971 Neighboring gene predicted gene, 38874

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info

    General protein information

    Preferred Names
    ER membrane protein complex subunit 3
    partial optokinetic response b
    transmembrane protein 111

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175101.3NP_780310.1  ER membrane protein complex subunit 3

      See identical proteins and their annotated locations for NP_780310.1

      Status: PROVISIONAL

      Source sequence(s)
      Consensus CDS
      Q3TIK3, Q99KI3
      ENSMUSP00000032425.6, ENSMUST00000032425.7
      Conserved Domains (1) summary
      DUF106; Integral membrane protein DUF106

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000072.7 Reference GRCm39 C57BL/6J

      113491848..113508599 complement
      GenBank, FASTA, Sequence Viewer (Graphics)