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    Abhd6 abhydrolase domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 66082, updated on 31-Jan-2019

    Summary

    Official Symbol
    Abhd6provided by MGI
    Official Full Name
    abhydrolase domain containing 6provided by MGI
    Primary source
    MGI:MGI:1913332
    See related
    Ensembl:ENSMUSG00000025277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA673485; AV065425; 0610041D24Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 11.3), large intestine adult (RPKM 9.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Abhd6 in Genome Data Viewer
    Location:
    14; 14 A1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (8002803..8056773)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (8835416..8889069)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene 45521 Neighboring gene deoxyribonuclease 1-like 3 Neighboring gene predicted gene, 30244 Neighboring gene predicted gene, 41094 Neighboring gene ribonuclease P 14 subunit Neighboring gene PX domain containing serine/threonine kinase Neighboring gene ribosomal protein L13 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    monoacylglycerol lipase ABHD6
    Names
    2-arachidonoylglycerol hydrolase
    NP_079617.2
    XP_006518136.1
    XP_006518137.1
    XP_006518138.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331064.1NP_001317993.1  monoacylglycerol lipase ABHD6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC139029, AK076105, AK168782, BE624233, BQ176347
      Consensus CDS
      CCDS26808.1
      UniProtKB/Swiss-Prot
      Q8R2Y0
    2. NM_001331065.1NP_001317994.1  monoacylglycerol lipase ABHD6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region and initiates translation from a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC139029, AK168782, BQ176347
      UniProtKB/Swiss-Prot
      Q8R2Y0
      UniProtKB/TrEMBL
      Q9D375
    3. NM_025341.4NP_079617.2  monoacylglycerol lipase ABHD6 isoform 1

      See identical proteins and their annotated locations for NP_079617.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA261636, AC139029, AK168782, BQ176347, BY253400, CX239001
      Consensus CDS
      CCDS26808.1
      UniProtKB/Swiss-Prot
      Q8R2Y0
      Related
      ENSMUSP00000129169.1, ENSMUST00000166497.8
      Conserved Domains (2) summary
      COG0596
      Location:51327
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:71160
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      8002803..8056773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518075.3XP_006518138.1  monoacylglycerol lipase ABHD6 isoform X2

      Related
      ENSMUSP00000153068.1, ENSMUST00000225234.1
      Conserved Domains (2) summary
      COG0596
      Location:4280
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:24113
      Abhydrolase; alpha/beta hydrolases
    2. XM_006518074.2XP_006518137.1  monoacylglycerol lipase ABHD6 isoform X1

      Related
      ENSMUSP00000026313.3, ENSMUST00000026313.3
      Conserved Domains (2) summary
      COG0596
      Location:51327
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:71160
      Abhydrolase; alpha/beta hydrolases
    3. XM_006518073.2XP_006518136.1  monoacylglycerol lipase ABHD6 isoform X1

      See identical proteins and their annotated locations for XP_006518136.1

      UniProtKB/Swiss-Prot
      Q8R2Y0
      Conserved Domains (2) summary
      COG0596
      Location:51327
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:71160
      Abhydrolase; alpha/beta hydrolases
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