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    Ppil2 peptidylprolyl isomerase (cyclophilin)-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 66053, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ppil2provided by MGI
    Official Full Name
    peptidylprolyl isomerase (cyclophilin)-like 2provided by MGI
    Primary source
    MGI:MGI:2447857
    See related
    Ensembl:ENSMUSG00000022771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CYC4; AA589416; 0610009L05Rik; 1700016N17Rik; 4921520K19Rik; 4930511F14Rik; C130078A06Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 36.1), mammary gland adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppil2 in Genome Data Viewer
    Location:
    16; 16 A3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16904419..16929126, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17086555..17111263, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (17086648..17111306, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6438 Neighboring gene mitogen-activated protein kinase 1 Neighboring gene yippee like 1 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b Neighboring gene microRNA 301b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RING-type E3 ubiquitin-protein ligase PPIL2
    Names
    PPIase
    RING-type E3 ubiquitin transferase isomerase-like 2
    cyclophilin-60
    cyclophilin-like protein Cyp-60
    peptidyl-prolyl cis-trans isomerase-like 2
    probable inactive peptidyl-prolyl cis-trans isomerase-like 2
    rotamase PPIL2
    NP_001239373.1
    NP_001239374.1
    NP_001343315.1
    NP_659203.1
    XP_006522506.1
    XP_006522508.1
    XP_006522509.1
    XP_006522510.1
    XP_030105088.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252444.1NP_001239373.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1

      See identical proteins and their annotated locations for NP_001239373.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI837084, AK012472, BY033661, BY145175
      Consensus CDS
      CCDS27993.1
      UniProtKB/Swiss-Prot
      Q9D787
      Related
      ENSMUSP00000023455.6, ENSMUST00000023455.14
      Conserved Domains (2) summary
      smart00504
      Location:4296
      Ubox; Modified RING finger domain
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...
    2. NM_001252445.1NP_001239374.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1

      See identical proteins and their annotated locations for NP_001239374.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC154667, AK161596, BY033661
      Consensus CDS
      CCDS27993.1
      UniProtKB/Swiss-Prot
      Q9D787
      Related
      ENSMUSP00000155861.2, ENSMUST00000231712.2
      Conserved Domains (2) summary
      smart00504
      Location:4296
      Ubox; Modified RING finger domain
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...
    3. NM_001356386.1NP_001343315.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154667
      Conserved Domains (1) summary
      cd01923
      Location:103262
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
    4. NM_144954.3NP_659203.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1

      See identical proteins and their annotated locations for NP_659203.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC154667
      Consensus CDS
      CCDS27993.1
      UniProtKB/Swiss-Prot
      Q9D787
      Related
      ENSMUSP00000131422.3, ENSMUST00000164458.10
      Conserved Domains (2) summary
      smart00504
      Location:4296
      Ubox; Modified RING finger domain
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16904419..16929126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522447.5XP_006522510.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X3

      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_006522443.5XP_006522506.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1

      Conserved Domains (4) summary
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl00197
      Location:281410
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. XM_006522445.5XP_006522508.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2

      See identical proteins and their annotated locations for XP_006522508.1

      Conserved Domains (1) summary
      cd01923
      Location:103262
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
    4. XM_030249228.1XP_030105088.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2

      Conserved Domains (1) summary
      cd01923
      Location:103262
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
    5. XM_006522446.5XP_006522509.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2

      See identical proteins and their annotated locations for XP_006522509.1

      Conserved Domains (1) summary
      cd01923
      Location:103262
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
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