SLC2A11 solute carrier family 2 member 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC2A11provided by HGNC
Official Full Name: solute carrier family 2 member 11provided by HGNC
Primary source: HGNC:HGNC:14239
See related: Ensembl:ENSG00000133460 MIM:610367; AllianceGenome:HGNC:14239
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLUT10; GLUT11
Summary: This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression: Ubiquitous expression in kidney (RPKM 6.0), brain (RPKM 3.5) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 22q11.23

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (23856934..23886312)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (24301547..24330924)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (24199121..24228499)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer.
Title: Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
Observational study of gene-disease association. (HuGE Navigator)
Title: Risk of meningioma and common variation in genes related to innate immunity.
GLUT11 can also transport fructose, but it has the motif DSV at the same position, which appears to function in the same manner as NXI and when all three residues are replaced with NAV fructose transport lost.
Title: A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity.
a novel sugar transporter that is alternatively spliced in various tissues
Title: Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues.
Different promoters and splicing generate three SLC2A11 isoforms which are expressed in a tissue specific manner but do not appear to differ in their functional characteristics.
Title: Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

NoName (e-PCR)
- UniSTS:482864

D8S2279 (e-PCR)
- UniSTS:473907

D15S1477 (e-PCR)
- UniSTS:474482

G27734 (e-PCR)
- UniSTS:81075

RH93042 (e-PCR)
- UniSTS:91133

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fructose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables hexose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sugar transmembrane transporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in fructose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in hexose transmembrane transport	TAS Traceable Author Statement more info
involved_in monosaccharide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 11

Names: facilitative glucose transporter GLUT11; glucose transporter protein 10; glucose transporter protein 11; glucose transporter type 10; glucose transporter type 11; glucose transporter-like protein XI; solute carrier family 2 (facilitated glucose transporter), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024938.4 → NP_001020109.1 solute carrier family 2, facilitated glucose transporter member 11 isoform c

See identical proteins and their annotated locations for NP_001020109.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as SLC2A11-a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (c, also known as GLUT11-S) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AK075467, AP000350, BC018967

Consensus CDS

CCDS46673.1

UniProtKB/Swiss-Prot

E9PH55, Q542Y4, Q6ICJ5, Q8WXF9, Q8WYM4, Q9BYW1

UniProtKB/TrEMBL

Q8WYM5

Related

ENSP00000342542.5, ENST00000345044.10

Conserved Domains (1) summary

cd17432
Location:16 → 467

MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
NM_001024939.4 → NP_001020110.1 solute carrier family 2, facilitated glucose transporter member 11 isoform b

See identical proteins and their annotated locations for NP_001020110.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as SLC2A11-c) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AK092466, AP000350, DC303452

Consensus CDS

CCDS33616.1

UniProtKB/TrEMBL

Q8WYM3

Related

ENSP00000326748.8, ENST00000316185.9

Conserved Domains (2) summary

cd06174
Location:64 → 460

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 471

Sugar_tr; Sugar (and other) transporter
NM_001282864.2 → NP_001269793.1 solute carrier family 2, facilitated glucose transporter member 11 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1, one of which results in a frameshift. The encoded isoform (d) is longer and has a distinct C- terminus, compared to isoform a.

Source sequence(s)

AK092466, AK300196, AP000350

Consensus CDS

CCDS74828.1

UniProtKB/TrEMBL

A0A087X018, B7Z6F0

Related

ENSP00000483038.1, ENST00000611880.4

Conserved Domains (2) summary

cd06174
Location:68 → 217

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:22 → 428

Sugar_tr; Sugar (and other) transporter
NM_030807.5 → NP_110434.3 solute carrier family 2, facilitated glucose transporter member 11 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as SLC2A11-b) encodes isoform a (also known as GLUT11-L).

Source sequence(s)

AJ271290, AK092466, AK314502, AP000350

Consensus CDS

CCDS13818.1

UniProtKB/TrEMBL

Q504W2

Related

ENSP00000381399.2, ENST00000398356.6

Conserved Domains (2) summary

cd06174
Location:68 → 464

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:22 → 475

Sugar_tr; Sugar (and other) transporter

RNA

NR_104247.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two internal exons and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK092466, AP000350, BC100810, DA084206
NR_104248.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as SLC2A11-s) lacks multiple 3' exons and its 3' terminal exon extends past a splice site used in variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, results in an open reading frame that lacks an in-frame stop codon.

Source sequence(s)

BC063525, DA084206

Related

ENST00000467660.5