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    CHID1 chitinase domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 66005, updated on 3-Apr-2024

    Summary

    Official Symbol
    CHID1provided by HGNC
    Official Full Name
    chitinase domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:28474
    See related
    Ensembl:ENSG00000177830 MIM:615692; AllianceGenome:HGNC:28474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GL008; SICLP; SI-CLP
    Summary
    Enables oligosaccharide binding activity. Involved in negative regulation of cytokine production involved in inflammatory response. Located in several cellular components, including late endosome; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 12.9), spleen (RPKM 11.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CHID1 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (867859..915214, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (919274..966273, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (867859..914845, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:840788-841532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:841533-842278 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:842279-843022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3045 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:843356-843524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:854507-855020 Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:858925-859458 Neighboring gene tetraspanin 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:859459-859992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:859993-860525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:860526-861060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:863729-864262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:865863-866396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:870607-871369 Neighboring gene extensin-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:889730-890249 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:891289-891806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:891807-892326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:893960-894462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:897610-898120 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:903420-903590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3048 Neighboring gene Sharpr-MPRA regulatory region 4982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:920183-920682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:937789-938701 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:940609-941519 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:942997-943671 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:944346-945020 Neighboring gene adaptor related protein complex 2 subunit alpha 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:945021-945694 Neighboring gene Sharpr-MPRA regulatory region 620 Neighboring gene RNA, U6 small nuclear 1025, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:953983-954591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:954699-955362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:955363-956024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:969867-970368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:970369-970868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:994284-994808 Neighboring gene mucin 6, oligomeric mucus/gel-forming

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with CHID1; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3234, FLJ42707

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oligosaccharide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    chitinase domain-containing protein 1
    Names
    stabilin-1 interacting chitinase-like protein
    NP_001136146.1
    NP_001136147.1
    NP_001136148.1
    NP_001136149.1
    NP_076436.3
    XP_011518601.1
    XP_011518602.1
    XP_011518603.1
    XP_011518604.1
    XP_016873655.1
    XP_016873656.1
    XP_024304431.1
    XP_047283435.1
    XP_047283436.1
    XP_047283437.1
    XP_047283438.1
    XP_047283439.1
    XP_047283440.1
    XP_047283441.1
    XP_047283442.1
    XP_054225699.1
    XP_054225700.1
    XP_054225701.1
    XP_054225702.1
    XP_054225703.1
    XP_054225704.1
    XP_054225705.1
    XP_054225706.1
    XP_054225707.1
    XP_054225708.1
    XP_054225709.1
    XP_054225710.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142674.2NP_001136146.1  chitinase domain-containing protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001136146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode isoform a.
      Source sequence(s)
      AP006623, BC000001, BI818660, CK904484
      Consensus CDS
      CCDS7722.1
      UniProtKB/Swiss-Prot
      B3KWB0, Q8NBM9, Q96CZ3, Q96S93, Q96SK0, Q9BWS9, Q9BY52
      UniProtKB/TrEMBL
      B7Z705
      Related
      ENSP00000388156.2, ENST00000436108.6
      Conserved Domains (1) summary
      cd02876
      Location:77393
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    2. NM_001142675.2NP_001136147.1  chitinase domain-containing protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001136147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode isoform a.
      Source sequence(s)
      AP006623, BC095409, BI821281, CK904484, DA983719
      Consensus CDS
      CCDS7722.1
      UniProtKB/Swiss-Prot
      B3KWB0, Q8NBM9, Q96CZ3, Q96S93, Q96SK0, Q9BWS9, Q9BY52
      UniProtKB/TrEMBL
      B7Z705
      Related
      ENSP00000391255.1, ENST00000449825.5
      Conserved Domains (1) summary
      cd02876
      Location:77393
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    3. NM_001142676.2NP_001136148.1  chitinase domain-containing protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001136148.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini but includes an additional segment, compared to isoform a.
      Source sequence(s)
      AK075413, AP006623, CK904484
      Consensus CDS
      CCDS44511.1
      UniProtKB/TrEMBL
      B7Z705
      Related
      ENSP00000435503.1, ENST00000528581.5
      Conserved Domains (2) summary
      cd02876
      Location:102418
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
      smart00636
      Location:106409
      Glyco_18; Glyco_18 domain
    4. NM_001142677.2NP_001136149.1  chitinase domain-containing protein 1 isoform c precursor

      See identical proteins and their annotated locations for NP_001136149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter than isoform a.
      Source sequence(s)
      AP006623, AY037151, CK904484
      Consensus CDS
      CCDS44510.1
      UniProtKB/TrEMBL
      B7Z705
      Related
      ENSP00000416034.2, ENST00000429789.6
      Conserved Domains (2) summary
      cd02876
      Location:77362
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
      smart00636
      Location:81353
      Glyco_18; Glyco_18 domain
    5. NM_023947.4NP_076436.3  chitinase domain-containing protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_076436.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode isoform a.
      Source sequence(s)
      AP006623, BC095409, CK904484
      Consensus CDS
      CCDS7722.1
      UniProtKB/Swiss-Prot
      B3KWB0, Q8NBM9, Q96CZ3, Q96S93, Q96SK0, Q9BWS9, Q9BY52
      UniProtKB/TrEMBL
      B7Z705
      Related
      ENSP00000325055.8, ENST00000323578.13
      Conserved Domains (1) summary
      cd02876
      Location:77393
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      867859..915214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520300.3XP_011518602.1  chitinase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B7Z705
      Conserved Domains (2) summary
      cd02876
      Location:162447
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
      smart00636
      Location:166438
      Glyco_18; Glyco_18 domain
    2. XM_011520299.3XP_011518601.1  chitinase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      B7Z705
      Conserved Domains (2) summary
      cd02876
      Location:162478
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
      smart00636
      Location:166469
      Glyco_18; Glyco_18 domain
    3. XM_047427479.1XP_047283435.1  chitinase domain-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      B3KWB0, Q8NBM9, Q96CZ3, Q96S93, Q96SK0, Q9BWS9, Q9BY52
    4. XM_047427480.1XP_047283436.1  chitinase domain-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      B3KWB0, Q8NBM9, Q96CZ3, Q96S93, Q96SK0, Q9BWS9, Q9BY52
    5. XM_047427484.1XP_047283440.1  chitinase domain-containing protein 1 isoform X8

    6. XM_047427481.1XP_047283437.1  chitinase domain-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      B3KWB0, Q8NBM9, Q96CZ3, Q96S93, Q96SK0, Q9BWS9, Q9BY52
    7. XM_017018166.2XP_016873655.1  chitinase domain-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      B3KWB0, Q8NBM9, Q96CZ3, Q96S93, Q96SK0, Q9BWS9, Q9BY52
      UniProtKB/TrEMBL
      B7Z705
      Conserved Domains (1) summary
      cd02876
      Location:77393
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    8. XM_011520301.4XP_011518603.1  chitinase domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      cd02876
      Location:162405
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
      smart00636
      Location:166397
      Glyco_18; Glyco_18 domain
    9. XM_047427485.1XP_047283441.1  chitinase domain-containing protein 1 isoform X9

    10. XM_024448663.2XP_024304431.1  chitinase domain-containing protein 1 isoform X7

      Conserved Domains (1) summary
      cd02876
      Location:77320
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
    11. XM_047427482.1XP_047283438.1  chitinase domain-containing protein 1 isoform X6

    12. XM_011520302.4XP_011518604.1  chitinase domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      cd02876
      Location:162404
      GH18_SI-CLP; Stabilin-1 interacting chitinase-like protein (SI-CLP) is a eukaryotic chitinase-like protein of unknown function that interacts with the endocytic/sorting transmembrane receptor stabilin-1 and is secreted from the lysosome. SI-CLP has a glycosyl ...
      smart00636
      Location:166397
      Glyco_18; Glyco_18 domain
    13. XM_047427483.1XP_047283439.1  chitinase domain-containing protein 1 isoform X10

    14. XM_047427486.1XP_047283442.1  chitinase domain-containing protein 1 isoform X11

    15. XM_017018167.3XP_016873656.1  chitinase domain-containing protein 1 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      919274..966273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369731.1XP_054225706.1  chitinase domain-containing protein 1 isoform X8

    2. XM_054369728.1XP_054225703.1  chitinase domain-containing protein 1 isoform X5

    3. XM_054369725.1XP_054225700.1  chitinase domain-containing protein 1 isoform X2

    4. XM_054369724.1XP_054225699.1  chitinase domain-containing protein 1 isoform X1

    5. XM_054369726.1XP_054225701.1  chitinase domain-containing protein 1 isoform X3

    6. XM_054369732.1XP_054225707.1  chitinase domain-containing protein 1 isoform X9

    7. XM_054369730.1XP_054225705.1  chitinase domain-containing protein 1 isoform X7

    8. XM_054369734.1XP_054225709.1  chitinase domain-containing protein 1 isoform X10

    9. XM_054369729.1XP_054225704.1  chitinase domain-containing protein 1 isoform X6

    10. XM_054369727.1XP_054225702.1  chitinase domain-containing protein 1 isoform X4

    11. XM_054369735.1XP_054225710.1  chitinase domain-containing protein 1 isoform X11

    12. XM_054369733.1XP_054225708.1  chitinase domain-containing protein 1 isoform X10